Microtubules are long, slender polymers of αβ-tubulin found in all eukaryotic cells. Tubulins
associate longitudinally to form protofilaments, and adjacent protofilaments associate …

The structure of tubulin has recently been determined by electron crystallography, paving
the way for a clearer understandin of the unique properties of tubulin that allow its varied …

Microtubules are non-covalent mesoscale polymers central to the eukaryotic cytoskeleton.
Microtubule structure, dynamics, and mechanics are modulated by a cell's choice of tubulin …

The cytoplasm of most eukaryotic cells is continuously remodeled by hundreds of growing or
shrinking microtubules. These polymers not only provide structural architecture to the …

Tubulin is known to exist in at least two main conformations: straight when bound to GTP or
buried within the microtubule lattice, and curved when bound to GDP. The latter is most …

Our knowledge of microtubule structure and its relationship to microtubule function
continues to grow. Cryo-elecron microscopy has given us new images of the microtubule …

Some 18 years ago, tubulin was originally identified as the soluble protein found in most
eukaryotic cells that tightly bound the antimitotic drug colchicine (1, 2). Quickly thereafter …

Next year will be the 50th anniversary of the discovery of tubulin. To celebrate this discovery,
six leaders in the field of microtubule research reflect on key findings and technological …

Microtubules are cytoskeletal filaments that are dynamically assembled from α/β-tubulin
heterodimers. The primary sequence and structure of the tubulin proteins and, consequently …

Microtubules are key cytoskeletal elements of all eukaryotic cells and are assembled of
evolutionarily conserved α-tubulin–β-tubulin heterodimers. Despite their uniform structure …