The hypothesis that separate neural systems mediate the reinforcing properties of opioid
and psychomotor stimulant drugs was tested by examining the role of mesolimbic dopamine …

The involvement of mesolimbic dopamine (DA) systems in motivational aspects of drug-
taking behavior during initiation of drug self-administration was investigated using a recently …

The hypothesis that separate neural systems mediate the reinforcing properties of opiate
and psychomotor stimulant drugs was tested in rats trained to lever-press for IV injections of …

The role of ascending noradrenergic (NA) and dopaminergic (DA) systems in intravenous
self-administration of cocaine in rats was investigated by examining the effects of 6 …

Both cocaine and cocaine-associated stimuli can reinstate extinguished self-administration
behavior in animals. It has been suggested that reinstatement of drug-seeking behavior may …

The involvement of dopamine D 1 receptor systems in the reinforcing properties of opiate
reward was studied by examining the effect of the dopamine D 1 antagonist SCH23390 on …

Hydroxydopamine-induced destruction of dopaminergic terminals in the nucleus accumbens
have been shown previously to disrupt cocaine and amphetamine self-administration. We …

The effect of 6-OHDA injections into the nucleus accumbens was examined on cocaine self-
administration behaviour. Rats were given access to cocaine (0.75 mg/kg/inj.) for three …

Studies indicate that nucleus accumbens (NAcc) dopamine neurotransmission is involved in
the reinforcing and direct effects of cocaine. The present study was initiated to explore …

The dopaminergic innervation of the nucleus accumbens is generally agreed to mediate the
primary reinforcing and locomotor effects of psychostimulants, but there is less consensus …