Highlights•Transcriptome studies suggest miRNAs can be used as microglia phenotype
markers.•MiR-124 regulates the quiescent state of microglia in the brain.•The immune role of …

MicroRNAs (miRNAs) are small noncoding RNAs that broadly affect cellular and
physiological function in all multicellular organisms. Here, the role of miRNAs in …

MicroRNAs (miRNAs) are a family of small non-coding RNAs (∼ 22 nucleotides) that fine-
tune protein expression by either silencing mRNA translation or directly targeting gene …

MicroRNAs (miRNAs) are single-stranded noncoding regions of approximately 21
nucleotides that regulate protein synthesis by targeting mRNAs for translational repression …

MicroRNAs (miRNAs) are an abundant class of small noncoding RNA molecules that play
an important role in the regulation of gene expression at the posttranscriptional level. Due to …

The central nervous system can respond to threat via the induction of an inflammatory
response. Under normal circumstances this response is tightly controlled, however …

Immunity and inflammation are important parameters of the pathophysiology of stroke, a
destructive illness that is the second most common cause of death worldwide. Following …

The significance of microglia and astrocytes in neural development, in maintaining synaptic
connections and homeostasis in the healthy brain is well established. Microglia are dynamic …

MicroRNAs (miRNAs) are small non-coding RNAs with a unique ability to regulate the
transcriptomic profile by binding to complementary regulatory RNA sequences. The ability of …

Microglia are the resident immune cells of the central nervous system and important
regulators of brain homeostasis. Central to this role is a dynamic phenotypic plasticity that …