Hydrogels are crosslinked polymeric materials that play a vital role in many biomedical
areas such as drug delivery, sensor technology, and tissue engineering. Increasing demand …

Since “click” chemistry was first reported in 2001, it has remained a popular research topic in
the field of chemistry due to its high yield without byproducts, fast reaction rate, simple …

In recent years, dynamic,'click'hydrogels have been applied in numerous biomedical
applications. Owing to the mild, cytocompatible, and highly specific reaction kinetics, a …

Highlights•Nano/microstructures can be incorporated into the hydrogels by various physical
or chemical cross-linking methods.•Nano/microstructures can enhance the mechanical …

Conspectus Stimuli-responsive hydrogels are intriguing biomaterials useful for
spatiotemporal controlled release of drugs, cells, and biological cues, cell engineering for …

This Review gives a brief introduction to hydrogels formed through click chemistry for
applications in tissue engineering. Specifically, we focus on three representative click …

Injectable hydrogels have attracted increasing attention in tissue regeneration and local
drug delivery applications. Current click reactions for preparing injectable hydrogels often …

Schiff base, an important family of reaction in click chemistry, has received significant
attention in the formation of self-healing hydrogels in recent years. Schiff base reversibly …

A novel and modular strategy has been developed for the preparation of reactive and
functionalized hydrogels. In this strategy, thiol–epoxy coupling chemistry was employed for …

Click chemistry is not a single specific reaction, but describes ways of generating products
which emulate examples in nature. Click reactions occur in one pot, are not disturbed by …