DNA methylation plays an important role in many biological processes. The mechanisms
underlying the establishment and maintenance of DNA methylation are well understood …

Genome-wide DNA methylation studies have quickly expanded due to advances in next-
generation sequencing techniques along with a wealth of computational tools to analyze the …

Studies of DNA methylation in Arabidopsis have rapidly advanced from the analysis of a
single reference accession to investigations of large populations. The goal of emerging …

The patterns of DNA methylation, referred to as the “methylome”, must be faithfully
propagated for proper development of plants and mammals. However, it has been unclear to …

Whole-genome bisulfite sequencing (WGBS) is the standard method for profiling DNA
methylation at single-nucleotide resolution. Different tools have been developed to extract …

Highlights•Epigenetic variation in plants is frequently linked to genetic variation.•Single large
effect mutations perturb the epigenetic landscape in trans.•DNA methylation regulates …

Cytosine methylation is an important base modification that is inherited across mitotic and
meiotic cell divisions in plant genomes. Heritable methylation variants can contribute to …

Epigenetic modifications play a vital role in the preservation of genome integrity and in the
regulation of gene expression. DNA methylation, one of the key mechanisms of epigenetic …

DNA methylation is a crucial epigenetic modification involved in multiple biological
processes and diseases. Current approaches for measuring genome-wide DNA methylation …

Cytosine DNA methylation is the addition of a methyl group to the 5′ position of a cytosine,
which plays a crucial role in plant development and gene silencing. Genome-wide profiling …