Cardiotoxicity remains a significant problem limiting the clinical usefulness of the cardiac
glycosides. Many recent studies have demonstrated that patients showing clear evidence of …

The appearance of various disorders of cardiac rhythms and conduction and nonspecific
symptoms in patients receiving digitalis is a common clinical problem. Practically all the …

Serum and myocardial digoxin levels were studied in 18 patients who came to autopsy. An
independent analysis of electrocardiograms prior to death was made to ascertain the …

The most important step in the management of toxicity due to any of the cardiac glycosides is
its recognition. Despite the development of an accurate clinical assay for serum levels of …

Nearly two centuries have passed since Withering published his' Account of the
Foxglove'with its classic descriptions of both the benefits and risks of cardiac glycosides …

For almost 2 centuries, dating from the original work of William Withering, considerable
interest and research has been applied to the mechanism and action of the cardiac …

The measurement of digoxin in plasma or serum using the technique of radioimmunoassay
is both rapid and reliable, and a relationship between the electro-cardiographic signs …

The 2 major factors affecting serum levels of the most commonly used cardiac glycoside
digoxin, are patient compliance and the physical characteristics of the tablet; the latter is …

Withering'first noted that individual patients vary both in the specific dose of digitalis required
to produce an effective therapeutic response and in their sensitivity to the serious toxic side …

Today, ALMOST TWO CENTURIES after Withering first reported that digitalis “has a power
over the motion of the heart, to a degree yet unobserved in any other medicine,” this …