Tumour-induced angiogenesis is a complex biological process that involves growth of new
blood vessels within the tumour microenvironment and is an important target for cancer …

Recent advances in microfluidic technologies have opened the door for creating more
realistic in vitro cell culture methods that replicate many aspects of the true in vivo …

The integration of tissue engineering strategies with microfluidic technologies has enabled
the design of in vitro microfluidic culture models that better adapt to morphological changes …

Blood vessels control all stages of tumor development and therapy by defining the
physicochemical and cellular state of the tumor microenvironment. However, no …

Microfluidic technology has led to the development of advanced in vitro tumor platforms that
overcome the challenges of in vivo animal and in vitro two dimensional models. This paper …

The goal of this study is to calibrate a multiscale model of tumor angiogenesis with time-
resolved data to allow for systematic testing of mathematical predictions of vascular …

Angiogenesis, the development of new blood vessels from existing vasculature, is a key
process in normal development and pathophysiology. In vitro models are necessary for …

Understanding cell transport and adhesion dynamics under flow is important for many
biotransport problems. We investigated the influence of cell size, ligand coating density …

The directed migration of endothelial cells is an early and critical step in angiogenesis, or
new blood vessel formation. In this study, the polarization and chemotaxis of human …

Microfluidic cell culture platforms are ideal candidates for modeling the native tumor
microenvironment because they can precisely reconstruct in vivo cellular behavior …