Binding of the prototypical adenosine A2A receptor agonist CGS 21680 to the cerebral cortex of adenosine A1 and A2A receptor knockout mice
2‐p‐(2‐carboxyethylphenethylamino‐5′‐ethylcarboxamidoadenosine)(CGS 21680) is
considered the reference compound to study adenosine A2A receptors. However, CGS …
considered the reference compound to study adenosine A2A receptors. However, CGS …
Central adenosine A2A receptors: an overview
JL Moreau, G Huber - Brain research reviews, 1999 - Elsevier
Recent advances in molecular biology, biochemistry, cell biology and behavioral
pharmacology together with the development of more selective ligands to the various …
pharmacology together with the development of more selective ligands to the various …
[HTML][HTML] Dopamine D2 and adenosine A2A receptors regulate NMDA-mediated excitation in accumbens neurons through A2A–D2 receptor heteromerization
Bursting activity of striatal medium spiny neurons results from membrane potential
oscillations between a down-and an upstate that could be regulated by G-protein-coupled …
oscillations between a down-and an upstate that could be regulated by G-protein-coupled …
Adenosine receptor‐mediated modulation of dopamine release in the nucleus accumbens depends on glutamate neurotransmission and N‐methyl‐d‐aspartate …
D Quarta, J Borycz, M Solinas, K Patkar… - Journal of …, 2004 - Wiley Online Library
Adenosine, by acting on adenosine A1 and A2A receptors, exerts opposite modulatory roles
on striatal extracellular levels of glutamate and dopamine, with activation of A1 inhibiting …
on striatal extracellular levels of glutamate and dopamine, with activation of A1 inhibiting …
[HTML][HTML] Intracellular calcium levels determine differential modulation of allosteric interactions within G protein-coupled receptor heteromers
The pharmacological significance of the adenosine A 2A receptor (A 2A R)-dopamine D 2
receptor (D 2 R) heteromer is well established and it is being considered as an important …
receptor (D 2 R) heteromer is well established and it is being considered as an important …
Role of extracellular cysteine residues in the adenosine A2A receptor
E De Filippo, V Namasivayam, L Zappe, A El-Tayeb… - Purinergic …, 2016 - Springer
The G protein-coupled A 2A adenosine receptor represents an important drug target. Crystal
structures and modeling studies indicated that three disulfide bonds are formed between …
structures and modeling studies indicated that three disulfide bonds are formed between …
Preservation of striatal cannabinoid CB1 receptor function correlates with the antianxiety effects of fatty acid amide hydrolase inhibition
S Rossi, V De Chiara, A Musella, L Sacchetti… - Molecular …, 2010 - ASPET
The endocannabinoid anandamide (AEA) plays a crucial role in emotional control, and
inhibition of its degradation by the fatty acid amide hydrolase (FAAH) has a potent …
inhibition of its degradation by the fatty acid amide hydrolase (FAAH) has a potent …
[HTML][HTML] Endocannabinoids mediate neuron-astrocyte communication
M Navarrete, A Araque - Neuron, 2008 - cell.com
Cannabinoid receptors play key roles in brain function, and cannabinoid effects in brain
physiology and drug-related behavior are thought to be mediated by receptors present in …
physiology and drug-related behavior are thought to be mediated by receptors present in …
Down-regulation of the AMPA glutamate receptor subunits GluR1 and GluR2/3 in the rat cerebellum following pre- and perinatal Δ9-tetrahydrocannabinol exposure
I Suarez, G Bodega, J Fernández-Ruiz, JA Ramos… - The Cerebellum, 2004 - Springer
This paper reports the effects of pre-and perinatal exposure to Δ 9-tetrahydrocannabinol
(THC) on expression levels of specific AMPA glutamate receptor subunits (GluRl and …
(THC) on expression levels of specific AMPA glutamate receptor subunits (GluRl and …
Activation of G-proteins in brain by endogenous and exogenous cannabinoids
SR Childers - The AAPS journal, 2006 - Springer
The biological response to cannabinoid agonist begins when the agonist-bound receptor
activates G-protein G α subunits, thus initiating a cascade of signal transduction pathways …
activates G-protein G α subunits, thus initiating a cascade of signal transduction pathways …