The structure of the human A 2A adenosine receptor has been elucidated by X-ray
crystallography with a high affinity non-xanthine antagonist, ZM241385, bound to it. This …

Adenosine and dopamine are two important modulators of glutamatergic neurotransmission
in the striatum. However, conflicting reports exist about the role of adenosine and adenosine …

Two endocannabinoids, arachidonoyl ethanolamide (AEA) and 2‐arachidonoylglycerol (2‐
AG) bind and activate G‐protein‐coupled cannabinoid receptors, but limited data exist on …

Adenosine tonically inhibits synaptic transmission through actions at A1 receptors. It also
facilitates synaptic transmission, but it is unclear if this facilitation results from pre-and/or …

Endocannabinoids acting at the cannabinoid type 1 receptor (CB1R) are known to regulate
attention, cognition and mood. Previous studies have shown that, in the rat medial prefrontal …

Postsynaptic Ca2+ signal influences synaptic transmission through multiple mechanisms.
Some of them involve retrograde messengers that are released from postsynaptic neurons …

The function of striatal adenosine A 2A receptors (A 2A Rs) is well recognized because of
their high expression levels and the documented antagonistic interaction between A 2A Rs …

The A 2a adenosine receptor, a member of the G protein-coupled receptor family, is
important in the regulation of dopaminergic pathways of the brain and in platelet and …

In this study we investigated the effect of cannabinoids on 3H glutamate release from
hippocampal synaptosomes of rat and CB1‐null mutant mouse. In the rat, cannabinoid …

Cannabinoids, including Δ9-tetrahydrocannabinol (THC), bind to receptors that couple to G
io-proteins and inhibit adenylyl cyclase. However, like other G-protein-coupled receptors …