In vitro genotoxicity evaluation of PAHs in mixtures using experimental design
R Castel, V Tassistro, M Claeys-Bruno, L Malleret… - Toxics, 2023 - mdpi.com
Settled dusts are sinks for environmental pollutants, including Polycyclic Aromatic
Hydrocarbons (PAHs) that are ubiquitous, persistent, and carcinogenic. To assess their …
Hydrocarbons (PAHs) that are ubiquitous, persistent, and carcinogenic. To assess their …
Risk characterization and probabilistic concentration–response modeling of complex environmental mixtures using new approach methodologies (NAMs) data from …
Background: Risk assessment of chemical mixtures or complex substances remains a major
methodological challenge due to lack of available hazard or exposure data. Therefore, risk …
methodological challenge due to lack of available hazard or exposure data. Therefore, risk …
Persistent activation of DNA damage signaling in response to complex mixtures of PAHs in air particulate matter
IWH Jarvis, C Bergvall, M Bottai, R Westerholm… - Toxicology and applied …, 2013 - Elsevier
Complex mixtures of polycyclic aromatic hydrocarbons (PAHs) are present in air particulate
matter (PM) and have been associated with many adverse human health effects including …
matter (PM) and have been associated with many adverse human health effects including …
Comparative potency approach based on H2AX assay for estimating the genotoxicity of polycyclic aromatic hydrocarbons
M Audebert, F Zeman, R Beaudoin, A Pery… - Toxicology and applied …, 2012 - Elsevier
Polycyclic Aromatic Hydrocarbons (PAHs) constitute a family of over one hundred
compounds and can generally be found in complex mixtures. PAHs metabolites cause DNA …
compounds and can generally be found in complex mixtures. PAHs metabolites cause DNA …
Priorities and challenges in methodology for human health risk assessment from combined exposure to multiple chemicals
D Nikolopoulou, E Ntzani, K Kyriakopoulou… - Toxics, 2023 - mdpi.com
This paper reviews key elements in the assessment of human health effects from combined
exposure to multiple chemicals taking into consideration current knowledge and challenges …
exposure to multiple chemicals taking into consideration current knowledge and challenges …
Polycyclic aromatic hydrocarbons (PAHs) in indoor environments are still imposing carcinogenic risk
Polycyclic aromatic hydrocarbons (PAHs) are among the most health-relevant air pollutants.
Herein, we conducted meta-analysis and experimental validation to evaluate PAHs in our …
Herein, we conducted meta-analysis and experimental validation to evaluate PAHs in our …
In vitro genotoxicity of PAH mixtures and organic extract from urban air particles: Part II: Human cell lines
O Sevastyanova, B Binkova, J Topinka, RJ Sram… - Mutation Research …, 2007 - Elsevier
Principal aims of this study were at first, to find a relevant human derived cell line to
investigate the genotoxic potential of PAH-containing complex mixtures and second, to use …
investigate the genotoxic potential of PAH-containing complex mixtures and second, to use …
The Long Goodbye: Finally moving on from the relative potency approach to a mixtures approach for polycyclic aromatic hydrocarbons (PAHs)
LT Haber, AM Pecquet, MJ Vincent… - International Journal of …, 2022 - mdpi.com
For the past several decades, a relative potency approach has been used to estimate the
human health risks from exposure to polycyclic aromatic hydrocarbon (PAH) mixtures. Risk …
human health risks from exposure to polycyclic aromatic hydrocarbon (PAH) mixtures. Risk …
PAH-CALUX, an optimized bioassay for AhR-mediated hazard identification of polycyclic aromatic hydrocarbons (PAHs) as individual compounds and in complex …
B Pieterse, E Felzel, R Winter… - … science & technology, 2013 - ACS Publications
Polycyclic aromatic hydrocarbons (PAHs) represent a class of ubiquitously occurring
environmental compounds that are implicated in a wide range of toxicological effects …
environmental compounds that are implicated in a wide range of toxicological effects …
Effect of the chemical composition of organic extracts from environmental and industrial atmospheric samples on the genotoxicity of polycyclic aromatic hydrocarbons …
A Tarantini, T Douki, MB Personnaz… - Toxicological & …, 2011 - Taylor & Francis
Particulate organic matter (PM) present in the atmosphere is a complex mixture of chemicals
like polycyclic aromatic hydrocarbons (PAH) that may exert adverse health effects including …
like polycyclic aromatic hydrocarbons (PAH) that may exert adverse health effects including …