[HTML][HTML] Environmental risk assessment of biocidal products: identification of relevant components and reliability of a component-based mixture assessment

A Coors, P Vollmar, J Heim, F Sacher… - Environmental Sciences …, 2018 - Springer
Background Biocidal products are mixtures of one or more active substances (as) and a
broad range of formulation additives. There is regulatory guidance currently under …

In vitro cellular toxicity induced by extractable organic fractions of particles exhausted from urban combustion sources-Role of PAHs

E Velali, E Papachristou, A Pantazaki, A Besis… - Environmental …, 2018 - Elsevier
The bioactivity of the extractable organic matter (EOM) of particulate matter (PM) exhausted
from major urban combustion sources, including residential heating installations (wood …

[HTML][HTML] Mixture prioritization and testing: the importance of toxicokinetics

A Braeuning, P Marx-Stoelting - Archives of Toxicology, 2021 - Springer
The topic of mixture toxicity has gained increased awareness in the past few years.
Toxicological risk assessment is still mainly based on the analysis of individual compounds …

Mechanistic relationships between hepatic genotoxicity and carcinogenicity in male B6C3F1 mice treated with polycyclic aromatic hydrocarbon mixtures

TD Phillips, M Richardson, YSL Cheng, L He… - Archives of …, 2015 - Springer
The genotoxicity of a complex mixture [neutral fraction (NF)] from a wood preserving waste
and reconstituted mixture (RM) mimicking the NF with seven major polycyclic aromatic …

Application of a framework for grouping and mixtures toxicity assessment of PFAS: A closer examination of dose-additivity approaches

PE Goodrum, JK Anderson, AL Luz… - Toxicological …, 2021 - academic.oup.com
Environmental occurrence and biomonitoring data for per-and polyfluoroalkyl substances
(PFAS) demonstrate that humans are exposed to mixtures of PFAS. This article presents a …

Mutagenicity risk prediction of PAH and derivative mixtures by in silico simulations oriented from CYP compound I-mediated metabolic activation

C Chen, Y Min, X Li, D Chen, J Shen, D Zhang… - Science of the total …, 2021 - Elsevier
PAHs and their derivatives are the main sources of mutagenicity and carcinogenicity in
airborne particular matter and cause serious public health and environmental problems …

Synergistic and antagonistic interactions among organic and metallic components of the ambient particulate matter (PM) for the cytotoxicity measured by Chinese …

Y Wang, JV Puthussery, H Yu, V Verma - Science of The Total Environment, 2020 - Elsevier
Although PM 2.5 toxicity is known to be related to its chemical composition, the effect of
interactions among various particles' components on the toxicity is not well explored. To …

Genotoxicity and physicochemical characteristics of traffic‐related ambient particulate matter

TM de Kok, JG Hogervorst, JJ Briedé… - Environmental and …, 2005 - Wiley Online Library
Exposure to ambient particulate matter (PM) has been linked to several adverse health
effects. Since vehicular traffic is a PM source of growing importance, we sampled total …

Temporal variation in the genotoxic potential of urban air particulate matter

O Sevastyanova, Z Novakova, K Hanzalova… - … /Genetic Toxicology and …, 2008 - Elsevier
The main aim of this study was to compare the genotoxic potential of organic extracts from
urban air particles collected in three different sampling periods in the center of Prague …

Application of text mining in risk assessment of chemical mixtures: a case study of polycyclic aromatic hydrocarbons (PAHs)

I Ali, K Dreij, S Baker, J Högberg… - Environmental …, 2021 - ehp.niehs.nih.gov
Background: Cancer risk assessment of complex exposures, such as exposure to mixtures
of polycyclic aromatic hydrocarbons (PAHs), is challenging due to the diverse biological …