[HTML][HTML] Chemometric modeling of the lowest observed effect level (LOEL) and no observed effect level (NOEL) for rat toxicity

A Kumar, PK Ojha, K Roy - Environmental Science: Advances, 2024 - pubs.rsc.org
Humans and other living species of the ecosystem are constantly exposed to a wide range
of chemicals of natural as well as synthetic origin. A multitude of compounds exert profound …

[HTML][HTML] MRA Toolbox v. 1.0: a web-based toolbox for predicting mixture toxicity of chemical substances in chemical products

J Kim, M Seo, J Choi, M Na - Scientific Reports, 2022 - nature.com
The chemical risk assessment paradigm is shifting from “substance-based” to
“product/mixture-based” and from “animal testing” to “alternative testing” under chemical …

Cytotoxicity and genotoxicity induced in vitro by solvent-extractable organic matter of size-segregated urban particulate matter

E Velali, E Papachristou, A Pantazaki… - Environmental …, 2016 - Elsevier
Three organic fractions of different polarity, including a non polar organic fraction (NPOF), a
moderately polar organic fraction (MPOF), and a polar organic fraction (POF) were obtained …

Cytotoxicity of PM2. 5 and PM2. 5–10 ambient air pollutants assessed by the MTT and the Comet assays

WLW Hsiao, ZY Mo, M Fang, X Shi, F Wang - Mutation Research/Genetic …, 2000 - Elsevier
Ambient air particulate matters are classified into two distinct modes in size distribution,
namely the coarse and fine particles. Correlation between high particulate concentration …

Mutagenic interactions of model chemical mixtures

KC Donnelly, LD Claxton, HJ Huebner, JL Capizzi - Chemosphere, 1998 - Elsevier
Although current methodology for human health risk assessment assumes additive
interactions among the contaminants of a complex mixture, chemical interactions may occur …

Prioritizing selected PPCPs on the basis of environmental and toxicogenetic concerns: a toxicity estimation to confirmation approach

M Junaid, Y Wang, N Hamid, S Deng, WG Li… - Journal of hazardous …, 2019 - Elsevier
Pharmaceuticals and personal care products (PPCPs), the pollutants of emerging concerns,
present potential risks to the ecological environment. This study focused on the prioritization …

Interlaboratory evaluation of a multiplexed high information content in vitro genotoxicity assay

SM Bryce, DT Bernacki, JC Bemis… - Environmental and …, 2017 - Wiley Online Library
We previously described a multiplexed in vitro genotoxicity assay based on flow cytometric
analysis of detergent‐liberated nuclei that are simultaneously stained with propidium iodide …

A new hazard index of complex mixtures integrates bioconcentration and toxicity to refine the environmental risk assessment of effluents

S Gutiérrez, C Fernández, BI Escher… - Environment international, 2008 - Elsevier
A new methodology to evaluate the overall environmental hazard of unknown mixtures,
based on bioconcentration potential and toxicity, was developed using a combination of two …

An overall risk probability-based method for quantification of synergistic and antagonistic effects in health risk assessment for mixtures: Theoretical concepts

QJ Yu, Q Cao, DW Connell - Environmental science and pollution research, 2012 - Springer
Purpose In the assessment of health risks of environmental pollutants, the method of dose
addition and the method of independent action are used to assess mixture effects when no …

Overview, conclusions, and recommendations of the IPCS collaborative study on complex mixtures

LD Claxton, G Douglas, D Krewski, J Lewtas… - … Research/Reviews in …, 1992 - Elsevier
Abstract The International Programme on Chemical Safety (IPCS) sponsored an
international collaborative study to examine the variability associated with the extraction and …