Adenosine uptake (consisting of both membrane transport and subsequent metabolism) was
studied in mouse pancreatic islets in order to further evaluate the ability of adenosine to …

The effect of adenosine in insulin secretion and adenylate cyclase activity of rat islets of
Langerhans was investigated. Adenosine inhibited insulin secretion stimulated by glucose …

Mouse islets were used to study the effects of adenosine and its stable analogue L-N6-
phenylisopropyladenosine (L-PIA) on pancreatic beta-cell function. At a high concentration …

To test further the hypothesis that ribonucleosides stimulate insulin secretion and
biosynthesis by producing metabolic signals, the effects of starvation on adenosine …

The effects of adenosine on insulin and glucagon secretions were studied using the isolated
perfused rat pancreas. The secretion of glucagon was stimulated by adenosine at …

Under physiological conditions, insulin secretion from pancreatic β-cells is tightly regulated
by different factors, including nutrients, nervous system, and other hormones. Pancreatic β …

Adenosine (1.0–100 μm). N 6-phenylisopropyladenosine (0.1–10 μm) and 2-
deoxyadenosine (10 mm) all produced a dose-dependent inhibition of glucose-stimulated …

Bovine adrenal chromaffin cells in culture have a high capacity and affinity for adenosine
uptake with Vmax= 14+/-2.4 pmol/10 (6) cells/min (133 pmol/mg of protein/min) and Km= 1+ …

Adenosine is known to influence different kinds of cells, including β-cells of the pancreas.
However, the role of this nucleoside in the regulation of insulin secretion is not fully …

Cultured mouse pancreatic islets were prelabelled with 2-3 H-adenosine in order to monitor
the efflux pattern of radioactivity and insulin. The outflow of radioactivity decreased …