Background: Temporomandibular disorders (TMDs) are characterized by persistent orofacial
pain and have diverse etiologic factors that are not well understood. It is thought that central …

Voltage-gated K+ (Kv) channels are one of the important physiological regulators of the
membrane potentials in excitable cells, including sensory ganglion neurons. The aim of the …

Osteoarthritic pain has a strong impact on patients' quality of life. Understanding the
pathogenic mechanisms underlying osteoarthritic pain will likely lead to the development of …

Background: Refractory chronic pain dramatically reduces the quality of life of patients.
Existing drugs cannot fully achieve effective chronic pain control because of their lower …

Neuropathic pain induced by chemotherapy drugs such as oxaliplatin is a dose-limiting side
effect in cancer treatment. The mechanisms underlying chemotherapy-induced neuropathic …

Bone cancer pain has a strong impact on the quality of life of patients, but is difficult to treat.
Better understanding of the pathogenic mechanisms underlying bone cancer pain will likely …

Previous studies in several different trigeminal nerve injury/inflammation models indicated
that the hyperexcitability of primary afferent neurons contributes to the pain pathway …

Treatment of chronic pain remains an unmet medical need. The neuronal voltage-gated
potassium Kv7/KCNQ/M channel has been implicated as a therapeutic target for chronic …

Aims To investigate cellular changes in the spinal trigeminal nucleus (STN) and trigeminal
ganglion associated with trigeminal nociception mediated by inflammation in the …

Background Diabetic neuropathic pain is poorly controlled by analgesics, and the precise
molecular mechanisms underlying hyperalgesia remain unclear. The KCNQ2/3/5 channels …