The complex response pattern of an organismus to stress, ie, to threatening external or
internal events such as noxious stimuli or pain, includes cardiovascular, behavioral, and …

Desensitization and cross-desensitization to the cardiovascular and behavioral effects
elicited by intracerebroventricular (icv) substance P (SP) and neurokinin A (NKA) injections …

The neurokinins, substance P (SP) and neurokinin A (NKA) represent natural, nonspecific
ligands of NK1 and NK2receptors. In our study in conscious rats, we tested the hypothesis …

Multiple neurochemicals coexist in individual neurons and may play a role in chemical
communication.'Tachykinins were in the forefront of putative transmitters studied for …

Tachykinins are a family of neuropeptides, which act by binding to three main subtypes of G
protein-coupled receptors, named NK1, NK2 and NK3. Tachykinins are contained in both …

To identify the tachykinin receptor subclass involved in the central cardiovascular and
behavioral actions of substance P (SP), we compared the central actions of SP with those of …

Intravenous injection of 3–33 nmol/kg of substance P (SP) caused pressor and tachycardic
responses in anesthetized rats. The responses were not blocked by a ganglion nicotinic …

1. The precise physical definitions of stress as a force per unit area and of strain as the
deformation of a solid subjected to that force are conceptually similar to the demands placed …

Evidence from pharmacological studies has implicated substance P (SP), a natural ligand of
tachykinin NK1 receptors which can also interact with NK2 receptors, in the generation of …

The term “tachykinin,” which literally means “fast acting,” refers to a family of peptides that
contains the C-terminal sequence of-Phe-X-Gly-Leu-Met-NH 2. The best known of these …