Continuous acceleration of neural activity of the GnRH pulse generator during chronic peripheral infusion of neurokinin 3 receptor agonist in goats

T Yamamura, H Okamura… - Journal of Reproduction …, 2023 - jstage.jst.go.jp
Secretion of pulsatile gonadotropin-releasing hormone (GnRH) is essential for reproduction.
Kisspeptin neurons in the arcuate nucleus (ARC), which coexpress neurokinin B (NKB) and …

Local administration of Neurokinin B in the arcuate nucleus accelerates the neural activity of the GnRH pulse generator in goats

Y Wakabayashi, H Okamura… - Journal of Reproduction …, 2021 - jstage.jst.go.jp
Kisspeptin neurons in the arcuate nucleus (ARC), which co-express neurokinin B (NKB) and
dynorphin A, are termed KNDy neurons. These neurons are candidates for the intrinsic …

Electrophysiological and morphological evidence for synchronized GnRH pulse generator activity among Kisspeptin/neurokinin B/dynorphin A (KNDy) neurons in …

Y Wakabayashi, T Yamamura, K Sakamoto… - … of Reproduction and …, 2013 - jstage.jst.go.jp
Neurons in the arcuate nucleus (ARC) that concomitantly express kisspeptin, neurokinin B
(NKB) and dynorphin A are termed KNDy neurons and are likely candidates for the intrinsic …

Continuous kisspeptin restores luteinizing hormone pulsatility following cessation by a neurokinin B antagonist in female sheep

IJ Clarke, Q Li, BA Henry, RP Millar - Endocrinology, 2018 - academic.oup.com
Pulsatile secretion of the gonadotropin-releasing hormone (GnRH) drives pulsatile secretion
of the luteinizing hormone (LH), with evidence that this depends on kisspeptin (Kiss) input to …

Kisspeptin, neurokinin B, and dynorphin act in the arcuate nucleus to control activity of the GnRH pulse generator in ewes

RL Goodman, SM Hileman, CC Nestor, KL Porter… - …, 2013 - academic.oup.com
Recent work has led to the hypothesis that kisspeptin/neurokinin B/dynorphin (KNDy)
neurons in the arcuate nucleus play a key role in GnRH pulse generation, with kisspeptin …

Kisspeptin and GnRH pulse generation

H Okamura, H Tsukamura, S Ohkura… - Kisspeptin Signaling in …, 2013 - Springer
The reproductive neuropeptide gonadotropin-releasing hormone (GnRH) has two modes of
secretion. Besides the surge mode, which induces ovulation in females, the pulse mode of …

Lesions of KNDy and Kiss1R neurons in the arcuate nucleus produce different effects on LH pulse patterns in female sheep

RL Goodman, AM Moore, K Onslow, SM Hileman… - …, 2023 - academic.oup.com
The current model for the synchronization of GnRH neural activity driving GnRH and LH
pulses proposes that a set of arcuate (ARC) neurons that contain kisspeptin, neurokinin B …

Neurokinin B and dynorphin A in kisspeptin neurons of the arcuate nucleus participate in generation of periodic oscillation of neural activity driving pulsatile …

Y Wakabayashi, T Nakada, K Murata… - Journal of …, 2010 - Soc Neuroscience
Gonadotropin-releasing hormone (GnRH) neurons in the basal forebrain are the final
common pathway through which the brain regulates reproduction. GnRH secretion occurs in …

New developments in kisspeptin, neurokinin B and dynorphin A regulation of gonadotropin-releasing hormone pulsatile secretion

RP Millar - Neuroendocrinology, 2014 - karger.com
The second article, by Goodman et al.[2], reviews the roles of kisspeptin, NKB and Dyn in
GnRH pulse generation as gathered from a comprehensive series of excellent studies in …

KNDy hypothesis for generation of GnRH pulses: evidence from sheep and goats

RL Goodman, S Ohkura, H Okamura… - The GnRH neuron …, 2018 - books.google.com
Although it has been recognized for over 4 decades that episodic GnRH secretion is a key
functional characteristic of the hypothalamic–pituitary–gonadal (HPG) axis, the underlying …