Biology of infection and disease pathogenesis to guide RSV vaccine development

S Boyoglu-Barnum, T Chirkova… - Frontiers in …, 2019 - frontiersin.org
Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract disease
in young children and a substantial contributor to respiratory tract disease throughout life …

Respiratory syncytial virus vaccines

RA Dudas, RA Karron - Clinical microbiology reviews, 1998 - Am Soc Microbiol
Respiratory syncytial virus (RSV) is the most important cause of viral lower respiratory tract
illness (LRI) in infants and children worldwide and causes significant LRI in the elderly and …

Respiratory syncytial virus subunit vaccine based on a recombinant fusion protein expressed transiently in mammalian cells

S Nallet, M Amacker, N Westerfeld, L Baldi, I König… - Vaccine, 2009 - Elsevier
Although respiratory syncytial virus (RSV) causes severe lower respiratory tract infection in
infants and adults at risk, no RSV vaccine is currently available. In this report, efforts toward …

Respiratory syncytial virus vaccine development

JS Kahn - Current opinion in pediatrics, 2000 - journals.lww.com
Respiratory syncytial virus is the major respiratory pathogen of infants and children
worldwide. Currently, there is no effective vaccine to protect against respiratory syncytial …

Challenges and opportunities in RSV vaccine development: meeting report from FDA/NIH workshop

JN Roberts, BS Graham, RA Karron, FM Munoz… - Vaccine, 2016 - Elsevier
Respiratory syncytial virus (RSV) is the most common cause of serious acute lower
respiratory illness in infants and young children and a significant cause of disease burden in …

Live-attenuated respiratory syncytial virus vaccines

RA Karron, UJ Buchholz, PL Collins - Challenges and opportunities for …, 2013 - Springer
Live-attenuated respiratory syncytial virus (RSV) vaccines offer several advantages for
immunization of infants and young children:(1) they do not cause vaccine-associated …

Respiratory syncytial virus subunit vaccines based on the viral envelope glycoproteins intended for pregnant women and the elderly

M Beugeling, J De Zee, HJ Woerdenbag… - Expert review of …, 2019 - Taylor & Francis
Introduction: Respiratory syncytial virus (RSV) causes high morbidity and mortality rates
among infants, young children, and the elderly worldwide. Unfortunately, a safe and effective …

Respiratory syncytial virus vaccine approaches: a current overview

CM Clark, A Guerrero-Plata - Current clinical microbiology reports, 2017 - Springer
Abstracts Purpose of Review Respiratory syncytial virus (RSV) is a global human pathogen
responsible for lower respiratory tract infections (LRTI). While RSV infection is innocuous in …

Respiratory syncytial virus vaccine: where are we now and what comes next?

A Noor, LR Krilov - Expert opinion on biological therapy, 2018 - Taylor & Francis
Introduction: Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract
infection in infants and elderly and to date, there is no safe or effective vaccine against RSV …

The non-structural proteins of RSV: targeting interferon antagonists for vaccine development

MN Teng - … Disorders-Drug Targets (Formerly Current Drug …, 2012 - ingentaconnect.com
Over fifty years have passed since the identification of respiratory syncytial virus (RSV) as an
important pediatric pathogen. However, an effective vaccine is still lacking. Immunization …