The Elongin BC-box protein family includes the von Hippel-Lindau tumor suppressor and
suppressor of cytokine signaling proteins, which are substrate recognition subunits of …

The heterodimeric Elongin BC complex has been shown to interact in vitro and in
mammalian cells with a conserved BC-box motif found in a growing number of proteins …

The heterodimeric Elongin BC complex has been shown to interact in vitro and in cells with
a conserved BC-box motif found in an increasing number of proteins including RNA …

The ECS (Elongin B/C-Cul2/Cul5-SOCS-box protein) complex is a member of a family of
ubiquitin ligases that share a Cullin-Rbx module. SOCS-box proteins recruit substrates to …

Cullins are members of a family of scaffold proteins that assemble multisubunit ubiquitin
ligase complexes to confer substrate specificity for the ubiquitination pathway. Cullin3 (Cul3) …

Protein ubiquitination plays an important role in regulating the abundance and conformation
of a broad range of eukaryotic proteins. This process involves a cascade of enzymes …

Cullin‐based E3 ligases target substrates for ubiquitin‐dependent degradation by the 26S
proteasome. The SCF (Skp1–Cul1–F‐box) and ECS (ElonginC–Cul2–SOCS box) …

Cullin-based E3 ligases are a large family of multi-subunit ubiquitin ligases with diverse
cellular functions, including the regulation of the cell cycle, of the DNA damage response …

Cullins (CULs) are subunits of a prominent class of RING ubiquitin ligases. Whereas the
subunits and substrates of CUL1-associated SCF complexes and CUL2 ubiquitin ligases …

The Elongin complex was originally identified as a positive regulator of RNA polymerase II
and is composed of a transcriptionally active subunit (A) and two regulatory subunits (B and …