Background Eosinophils act as a secondary antigen-presenting cell (APC) to stimulate Th
cell responses against antigens. IL-25 plays a significant role in eosinophil activation in …

Background Eosinophil-lineage committed progenitor cells (EoP) migrate from the bone
marrow and differentiate locally to provide an ongoing source of mature eosinophils in …

Background: Interleukin (IL)-25 plays a pivotal role in type 2 immune responses. In a
baseline cross-sectional study, we previously showed that IL-25 plasma levels and IL-25 …

IL-17 is known to play important roles in immune and inflammatory disease, such as in
asthma, but its functions in allergic airway inflammation are still controversial, and the …

The primary function of IL-7 is to promote maturation and survival of T cells. Through
microarray expression analysis, we previously observed that human blood eosinophils …

Background Interleukin-25 (IL-25) is a potent activator of type-2 immune responses, and is
responsible for airway inflammation in asthma. Previous reports have shown that IL-25 …

Allergic asthma occurs as a consequence of inappropriate immunologic inflammation to
allergens and characterized by Th2 adaptive immune response. Recent studies indicated …

BACKGROUND: A novel IL-17 family cytokine, IL-25, has been reported to induce IL-4, IL-5,
and IL-13 production from undefined non-T/non-B cells and then induce TH2-type immune …

Background IL‐35, a new member of the IL‐12 family, is an inhibitory cytokine produced by
regulatory T and B lymphocytes that play a suppressive role in the inflammatory diseases …

Background Differentiation and activation of CD 4+ T cells is controlled by various cytokines
produced by innate immune cells. We have shown that eosinophils (EOS) have the potential …