Objective Several RCTs have been conducted to assess the efficacy and safety of
angiotensin receptor blocker (ARB) and beta-blocker (BB) therapy for Marfan syndrome …

Summary Background Angiotensin receptor blockers (ARBs) and β blockers are widely used
in the treatment of Marfan syndrome to try to reduce the rate of progressive aortic root …

The Marfan syndrome (MFS) patients are highly predisposed to thoracic aortic aneurysm
and/or dissection, with virtually every patient having evidence of aortic disease at some point …

Rationale A number of randomized trials are underway, which will address the effects of
angiotensin receptor blockers (ARBs) on aortic root enlargement and a range of other end …

Background and purpose Variable effects of beta-blockers (BB) and/or angiotensin receptor
blockers (ARB) were reported to retard aortic root growth in Marfan syndrome (MFS). This …

Aims The COMPARE trial showed a small but significant beneficial effect of 3-year losartan
treatment on aortic root dilatation rate in adults with Marfan syndrome (MFS). However, no …

OBJECTIVE: To assess the effect of beta-blockade therapy on clinical outcome in patients
with Marfan's syndrome. BACKGROUND: Despite the lack of definitive evidence to support …

Objective To assess the tolerability and efficacy of the investigational use of the angiotensin
II receptor blocker losartan added to β-blockade (BB) to prevent progressive aortic root …

BackgroundMarfan syndrome causes aortic dilation leading to dissection and death. This
systematic review examined the use of beta-blockers, angiotensin-converting enzyme …

Background: Beta-blockers are the standard treatment in Marfan syndrome (MFS). Recent
clinical trials with limited follow-up yielded conflicting results on losartan's effectiveness in …