Background Myostatin, a cytokine produced by skeletal muscle, may influence Alzheimer's
disease (AD) pathogenesis, but sparse evidence exists in humans. We assessed the …

Background Myostatin is a negative regulator of muscle growth but the relationship between
serum myostatin levels and muscle mass is unclear. This study investigated the association …

Background: Myostatin has been proposed as a candidate biomarker for frailty and
sarcopenia. However, the relationship of myostatin with these conditions remains …

With aging, there are progressive functional declines in multiple organ systems. One of the
major physiological problems observed in aged people is skeletal muscle loss. This age …

Dear Editor, Arrieta et al.[1] investigated whether circulating myostatin concentrations were
associated with physical fitness and frailty. They selected male and female long-term …

BACKGROUND: Myostatin is a recently discovered member of the TGF-b superfamily of
genes. It is expressed in skeletal muscle and believed to suppress muscle growth. Myostatin …

Myostatin is a key negative regulator of muscle mass in humans and animals, having direct
and indirect influences on molecular regulators of atrophy and hypertrophy, thus may impact …

Background Myostatin (MSTN) is a key negative regulator of muscle mass in humans and
animals, having direct and indirect influences on molecular regulators of atrophy and …

We would like to thank Laurent et al. for their interest and comments about our article
published in Gerontology [1, 2]. We think that their statements show the way to future …

Objectives (i) To investigate serum myostatin (absolute and normalized for total body lean
mass (TBLM)) and IGF-1 as biomarkers of frailty and low relative appendicular skeletal …