Abstract Prostaglandin E2 (PGE2) plays a key role in the maintenance of human pregnancy
and labour onset. PGE2 can elicit diverse actions within the uterus depending on the PGE2 …

Context: Prostaglandins are central to the processes of human labor. Prostaglandin E2
(PGE2) synthesized within the uterus mediates cervical ripening and uterine contractions …

Prostaglandins (PGs) play important functions in the reproductive system, and PGE2
appears necessary for recognition of pregnancy. We have found that PGE2 is able to …

Inflammatory mediators, including prostaglandins, cytokines, and chemokines, are strongly
implicated in the mechanism of human labor, though their precise roles remain unknown …

Prostanoids, especially prostaglandin (PG) E2, are important mediators of uterine relaxation
and contractions during gestation and parturition. Inhibitors of PG formation as well as PG …

PGE2 is known to induce uterine contraction by increasing intracellular Ca2+. In the present
study, to investigate other functions of PGE2 in human uterus, two EP3 isoforms were …

As an initial step to clarify the mechanisms of various uterine actions of PGE2, expression
patterns of the messenger RNAs (mRNAs) for four subtypes of PGE receptors, EP1, EP2 …

In the present study, we characterized the mRNA abundance of prostaglandin E2 receptor
subtypes (EP1 and EP3, which stimulate excitatory responses; EP2 and EP4, which …

OBJECTIVE: The effects of prostaglandin E2 (PGE2) are mediated through G-protein
coupled receptors, acting via different second messengers. The aim of this study was to …

Prostaglandin (PG) E2and PGF2αare believed to play important roles in the myometrial
contraction and the initiation of labor. Myometrial contraction by these prostanoids is …