Introduction Spatial heterogeneity of lung aeration and strain (change volume/resting
volume) occurs at microscopic levels and contributes to lung injury. Yet, it is mostly assessed …

Rationale: The contribution of aeration heterogeneity to lung injury during early mechanical
ventilation of uninjured lungs is unknown. Objectives: To test the hypotheses that a strategy …

Lung perfusion magnitude and distribution are essential for oxygenation and, potentially,
lung inflammation and protection during acute respiratory distress syndrome (ARDS). Yet …

Rationale: Intratidal changes in regional lung aeration, as assessed with dynamic four-
dimensional computed tomography (CT; 4DCT), may indicate the processes of recruitment …

PET imaging with 18F-FDG followed by mathematic modeling of the pulmonary uptake rate
(Ki) is the gold standard for assessment of pulmonary inflammation in experimental studies …

Heterogeneity in regional end expiratory lung volume (EELV) may lead to variations in
regional strain (ε). High ε levels have been associated with ventilator‐associated lung injury …

Objective: It is known that ventilator-induced lung injury causes increased pulmonary
inflammation. It has been suggested that one of the underlying mechanisms may be strain …

Macrophagic lung infiltration is pivotal in the development of lung biotrauma because of
ventilation-induced lung injury (VILI). We assessed the performance of [11C](R)-PK11195, a …

Objectives To compare changes in aerated lung volumes measured by positron emission
tomography (PET) and inflation volume-pressure curve (V–P) of the respiratory system, and …

Abstract Image Functional Modeling (IFM) synthesizes three dimensional airway networks
with imaging and mechanics data to relate structure to function. The goal of this study was to …