Chicken melanoma differentiation-associated gene 5 (MDA5) recognizes infectious bursal disease virus infection and triggers MDA5-related innate immunity

CC Lee, CC Wu, TL Lin - Archives of virology, 2014 - Springer
The objective of the present study was to determine if chicken melanoma differentiation-
associated gene 5 (MDA5) senses infectious bursal disease virus (IBDV) infection to initiate …

Role of chicken melanoma differentiation-associated gene 5 in induction and activation of innate and adaptive immune responses to infectious bursal disease virus in …

CC Lee, CC Wu, TL Lin - Archives of virology, 2015 - Springer
The objective of the present study was to determine if chicken melanoma-differentiation-
associated gene 5 (MDA5) senses infectious bursal disease virus infection to induce innate …

gga-miR-142-5p attenuates IRF7 signaling and promotes replication of IBDV by directly targeting the chMDA5′ s 3′ untranslated region

W Ouyang, J Qian, Q Pan, J Wang, X Xia, X Wang… - Veterinary …, 2018 - Elsevier
Chicken melanoma differentiation-associated gene 5 (chMDA5) is a key pattern recognition
receptor (PRR) that recognizes RNA viral infections and initiates an antiviral innate immune …

Promoter structures and differential responses to viral and non-viral inducers of chicken melanoma differentiation-associated gene 5

WX Zhang, EW Zuo, Y He, DY Chen, X Long… - Molecular …, 2016 - Elsevier
Melanoma differentiation-associated gene 5 (MDA5) is a member of the retinoic acid-
inducible gene I (RIG-I)-like receptors (RLRs) family and plays a pivotal role in the anti-viral …

Duck MDA5 functions in innate immunity against H5N1 highly pathogenic avian influenza virus infections

L Wei, J Cui, Y Song, S Zhang, F Han, R Yuan… - Veterinary …, 2014 - Springer
Melanoma differentiation-associated gene 5 (MDA5) is an important intracellular receptor
that recognizes long molecules of viral double-stranded RNA in innate immunity. To …

Avian infectious bronchitis virus disrupts the melanoma differentiation associated gene 5 (MDA5) signaling pathway by cleavage of the adaptor protein MAVS

L Yu, X Zhang, T Wu, J Su, Y Wang, Y Wang… - BMC veterinary …, 2017 - Springer
Background Melanoma differentiation associated gene 5 (MDA5) and retinoic acid-inducible
gene-I (RIG-I) selectively sense cytoplasmic viral RNA to induce an antiviral immune …

LGP2 plays a critical role in MDA5-mediated antiviral activity against duck enteritis virus

H Huo, LL Zhao, DF Wang, XH Chen, HY Chen - Molecular immunology, 2019 - Elsevier
Duck viral enteritis (DEV) is a DNA virus that leads to heavy economic losses in the
commercial duck industry. As a key cytoplasmic sensor, melanoma differentiation …

[HTML][HTML] Identification and expression profiling analysis of goose melanoma differentiation associated gene 5 (MDA5) gene

LM Wei, PR Jiao, YF Song, F Han, L Cao, F Yang… - Poultry Science, 2013 - Elsevier
Melanoma differentiation associated gene 5 (MDA5) is an important cytoplasmic receptor
that recognizes long molecules of viral double-stranded RNA and single-stranded RNA with …

Inhibition of antiviral innate immunity by birnavirus VP3 protein via blockage of viral double-stranded RNA binding to the host cytoplasmic RNA detector MDA5

C Ye, L Jia, Y Sun, B Hu, L Wang, X Lu… - Journal of virology, 2014 - Am Soc Microbiol
ABSTRACT Chicken MDA5 (chMDA5), the sole known pattern recognition receptor for
cytoplasmic viral RNA in chickens, initiates type I interferon (IFN) production. Infectious …

Characterization of chicken melanoma differentiation-associated gene 5 (MDA5) from alternative translation initiation

CC Lee, CC Wu, TL Lin - Comparative immunology, microbiology and …, 2012 - Elsevier
The present study was undertaken to identify and characterize chicken melanoma
differentiation-associated gene 5 (MDA5) from alternative translation initiation. The …