Tumour-on-a-chip: microfluidic models of tumour morphology, growth and microenvironment
Cancer remains one of the leading causes of death, albeit enormous efforts to cure the
disease. To overcome the major challenges in cancer therapy, we need to have a better …
disease. To overcome the major challenges in cancer therapy, we need to have a better …
Cancer Models on Chip: Paving the Way to Large‐Scale Trial Applications
Cancer kills millions of individuals every year all over the world (Global Cancer
Observatory). The physiological and biomechanical processes underlying the tumor are still …
Observatory). The physiological and biomechanical processes underlying the tumor are still …
Tumor-on-a-chip: from bioinspired design to biomedical application
X Liu, J Fang, S Huang, X Wu, X Xie, J Wang… - Microsystems & …, 2021 - nature.com
Cancer is one of the leading causes of human death, despite enormous efforts to explore
cancer biology and develop anticancer therapies. The main challenges in cancer research …
cancer biology and develop anticancer therapies. The main challenges in cancer research …
Cancer-on-a-chip: models for studying metastasis
Simple Summary Microfluidic-based cancer-on-a-chip models are powerful tools to study the
tumor microenvironment (TME). Two-dimensional cell culture cannot recapitulate TME. In …
tumor microenvironment (TME). Two-dimensional cell culture cannot recapitulate TME. In …
Ex vivo tumor‐on‐a‐chip platforms to study intercellular interactions within the tumor microenvironment
V Kumar, S Varghese - Advanced healthcare materials, 2019 - Wiley Online Library
The emergence of immunotherapies and recent FDA approval of several of them makes
them a promising therapeutic strategy for cancer. While these advancements underscore the …
them a promising therapeutic strategy for cancer. While these advancements underscore the …
Modelling cancer in microfluidic human organs-on-chips
A Sontheimer-Phelps, BA Hassell, DE Ingber - Nature Reviews Cancer, 2019 - nature.com
One of the problems that has slowed the development and approval of new anticancer
therapies is the lack of preclinical models that can be used to identify key molecular, cellular …
therapies is the lack of preclinical models that can be used to identify key molecular, cellular …
The tumor-on-chip: Recent advances in the development of microfluidic systems to recapitulate the physiology of solid tumors
G Trujillo-de Santiago, BG Flores-Garza… - Materials, 2019 - mdpi.com
The ideal in vitro recreation of the micro-tumor niche—although much needed for a better
understanding of cancer etiology and development of better anticancer therapies—is highly …
understanding of cancer etiology and development of better anticancer therapies—is highly …
Microengineered cancer-on-a-chip platforms to study the metastatic microenvironment
R Portillo-Lara, N Annabi - Lab on a chip, 2016 - pubs.rsc.org
More than 90% of cancer-related deaths can be attributed to the occurrence of metastatic
diseases. Recent studies have highlighted the importance of the multicellular, biochemical …
diseases. Recent studies have highlighted the importance of the multicellular, biochemical …
Tumor-on-a-chip for integrating a 3D tumor microenvironment: chemical and mechanical factors
Tumor progression, including metastasis, is significantly influenced by factors in the tumor
microenvironment (TME) such as mechanical force, shear stress, chemotaxis, and hypoxia …
microenvironment (TME) such as mechanical force, shear stress, chemotaxis, and hypoxia …
[HTML][HTML] Tumor-on-chip modeling of organ-specific cancer and metastasis
Every year, cancer claims millions of lives around the globe. Unfortunately, model systems
that accurately mimic human oncology–a requirement for the development of more effective …
that accurately mimic human oncology–a requirement for the development of more effective …