Macrophages in immunoregulation and therapeutics
S Chen, AFUH Saeed, Q Liu, Q Jiang, H Xu… - … and Targeted Therapy, 2023 - nature.com
Macrophages exist in various tissues, several body cavities, and around mucosal surfaces
and are a vital part of the innate immune system for host defense against many pathogens …
and are a vital part of the innate immune system for host defense against many pathogens …
Major pathways involved in macrophage polarization in cancer
C Kerneur, CE Cano, D Olive - Frontiers in immunology, 2022 - frontiersin.org
Macrophages play an important role in tissue homeostasis, tissue remodeling, immune
response, and progression of cancer. Consequently, macrophages exhibit significant …
response, and progression of cancer. Consequently, macrophages exhibit significant …
Macrophages as tools and targets in cancer therapy
A Mantovani, P Allavena, F Marchesi… - Nature Reviews Drug …, 2022 - nature.com
Tumour-associated macrophages are an essential component of the tumour
microenvironment and have a role in the orchestration of angiogenesis, extracellular matrix …
microenvironment and have a role in the orchestration of angiogenesis, extracellular matrix …
Macrophage's role in solid tumors: two edges of a sword
A Jahandideh, M Yarizadeh… - Cancer Cell …, 2023 - Springer
The tumor microenvironment is overwhelmingly dictated by macrophages, intimately
affiliated with tumors, exercising pivotal roles in multiple processes, including angiogenesis …
affiliated with tumors, exercising pivotal roles in multiple processes, including angiogenesis …
Tumor-associated macrophages as a paradigm of macrophage plasticity, diversity, and polarization: lessons and open questions
A Mantovani, M Locati - Arteriosclerosis, thrombosis, and vascular …, 2013 - Am Heart Assoc
Macrophages are present in all body compartments, including cancerous tissues, and their
functions are profoundly affected by signals from the microenvironment under homeostatic …
functions are profoundly affected by signals from the microenvironment under homeostatic …
The generation, activation, and polarization of monocyte-derived macrophages in human malignancies
P Chaintreuil, E Kerreneur, M Bourgoin… - Frontiers in …, 2023 - frontiersin.org
Macrophages are immune cells that originate from embryogenesis or from the differentiation
of monocytes. They can adopt numerous phenotypes depending on their origin, tissue …
of monocytes. They can adopt numerous phenotypes depending on their origin, tissue …
Mechanisms of macrophage plasticity in the tumor environment: manipulating activation state to improve outcomes
TD Ricketts, N Prieto-Dominguez, PS Gowda… - Frontiers in …, 2021 - frontiersin.org
Macrophages are a specialized class of innate immune cells with multifaceted roles in
modulation of the inflammatory response, homeostasis, and wound healing. While …
modulation of the inflammatory response, homeostasis, and wound healing. While …
Targeting tumor-infiltrating macrophages to combat cancer
RZ Panni, DC Linehan, DG DeNardo - Immunotherapy, 2013 - Taylor & Francis
Tumor-associated macrophages are one of the major constituents of tumor stroma in many
solid tumors and there is compelling preclinical and clinical evidence that macrophages …
solid tumors and there is compelling preclinical and clinical evidence that macrophages …
Harnessing the antitumor potential of macrophages for cancer immunotherapy
KB Long, GL Beatty - Oncoimmunology, 2013 - Taylor & Francis
Macrophages constitute a dominant fraction of the population of immune cells that infiltrate
developing tumors. Recruited by tumor-derived signals, tumor-infiltrating macrophages are …
developing tumors. Recruited by tumor-derived signals, tumor-infiltrating macrophages are …
[PDF][PDF] Macrophages and cancer
A Nardin, JP Abastado - Front Biosci, 2008 - article.imrpress.com
Macrophages are ubiquitous cells physiologically involved in a variety of processes
including pathogen destruction, inflammation, tissue repair and remodeling. They have a …
including pathogen destruction, inflammation, tissue repair and remodeling. They have a …