The germinal centre reaction selects B cells from a large diversity of clones in order to
optimise the efficiency of an immune response. We discuss two rather different approaches …

Germinal centres are anatomically defined lymphoid organ structures that mediate B-cell
affinity maturation and affect the quality of humoral immune responses. Mathematical …

During humoral immune responses some germinal centers (GCs) develop very well and
give rise to a large number of high affinity antibody producing plasma cells. Other GC …

The population dynamics theory of B cells in a typical germinal center could play an
important role in revealing how affinity maturation is achieved. However, the existing models …

During an immune response, the affinity of antibodies that react with the antigen that
triggered the response increases with time, a phenomenon known as affinity maturation. The …

During germinal center reactions, the appearance of two specific zones is observed: the
dark and the light zone. Up to now, the origin and function of these zones are poorly …

Affinity maturation of antibodies during immune responses is achieved by multiple rounds of
somatic hypermutation and subsequent preferential selection of those B cells that express B …

Mathematical modeling of complex biological systems has been shown to lead to
contradictory results. Two completely different approaches are compared using a highly …

The essential task of a germinal centre reaction is the selection of those B cells that bind the
antigen with high affinity. The exact mechanisms of B cell selection is still unknown and …

We introduce a generic reaction-diffusion model for germinal center reactions and perform
numerical simulations within a stochastic discrete event approach. In contrast to the …