Temporal profiling of the secretome during adipogenesis in humans

J Zhong, SA Krawczyk, R Chaerkady… - Journal of proteome …, 2010 - ACS Publications
Adipose tissue plays a key role as a fat-storage depot and as an endocrine organ. Although
mouse adipogenesis has been studied extensively, limited studies have been conducted to …

[HTML][HTML] Characterization of the human visceral adipose tissue secretome

G Alvarez-Llamas, E Szalowska, MP de Vries… - Molecular & Cellular …, 2007 - ASBMB
Adipose tissue is an endocrine organ involved in storage and release of energy but also in
regulation of energy metabolism in other organs via secretion of peptide and protein …

[HTML][HTML] In-depth analysis of the adipocyte proteome by mass spectrometry and bioinformatics

J Adachi, C Kumar, Y Zhang, M Mann - Molecular & Cellular Proteomics, 2007 - ASBMB
Adipocytes are central players in energy metabolism and the obesity epidemic, yet their
protein composition remains largely unexplored. We investigated the adipocyte proteome by …

[HTML][HTML] Identification and validation of novel adipokines released from primary human adipocytes

S Lehr, S Hartwig, D Lamers, S Famulla… - Molecular & cellular …, 2012 - ASBMB
Adipose tissue is a major endocrine organ, releasing signaling and mediator proteins,
termed adipokines, via which adipose tissue communicates with other organs. Expansion of …

Adipokines: a treasure trove for the discovery of biomarkers for metabolic disorders

S Lehr, S Hartwig, H Sell - PROTEOMICS–Clinical Applications, 2012 - Wiley Online Library
Adipose tissue is a major endocrine organ, releasing signaling and mediator proteins,
termed adipokines, via which adipose tissue communicates with other organs. Expansion of …

Secretome analysis of rat adipose tissues shows location-specific roles for each depot type

A Roca-Rivada, J Alonso, O Al-Massadi, C Castelao… - Journal of …, 2011 - Elsevier
Obesity prevalence is reaching pandemic proportions becoming a major public health threat
for many industrialized nations. It is especially worrying as it causes a higher risk of …

Temporal profiling of the adipocyte proteome during differentiation using a five-plex SILAC based strategy

H Molina, Y Yang, T Ruch, JW Kim… - Journal of proteome …, 2009 - ACS Publications
The adipose tissue has important secretory and endocrine functions in humans. The
regulation of adipocyte differentiation has been actively pursued using transcriptomic …

Functional annotation of the human fat cell secretome

I Dahlman, M Elsen, N Tennagels, M Korn… - … of physiology and …, 2012 - Taylor & Francis
Contex t: Recent secretome analyses suggest that human fat cells secrete hundreds of
proteins (adipokines). Objective: We made an overall analysis of their potential functional …

Characterization of the human adipocyte proteome and reproducibility of protein abundance by one-dimensional gel electrophoresis and HPLC− ESI− MS/MS

X Xie, Z Yi, B Bowen, C Wolf, CR Flynn… - Journal of proteome …, 2010 - ACS Publications
Abnormalities in adipocytes play an important role in various conditions, including the
metabolic syndrome, type 2 diabetes mellitus and cardiovascular disease, but little is known …

[HTML][HTML] Secretome of adipose tissue as the key to understanding the endocrine function of adipose tissue

D Pogodziński, L Ostrowska… - International journal of …, 2022 - mdpi.com
The prevalence of obesity has reached pandemic levels and is becoming a serious health
problem in developed and developing countries. Obesity is associated with an increased …