A germ cell‐specific ageing pattern in otherwise healthy men
S Laurentino, JF Cremers, B Horsthemke… - Aging …, 2020 - Wiley Online Library
Life‐long sperm production leads to the assumption that male fecundity remains unchanged
throughout life. However, recently it was shown that paternal age has profound …
throughout life. However, recently it was shown that paternal age has profound …
The inherited methylome landscape is directly altered with paternal aging and associated with offspring neurodevelopmental disorders
MM Denomme, ME Haywood, JC Parks… - Aging …, 2020 - Wiley Online Library
Paternal aging and the prevalence of neurodevelopmental disorders in offspring are well
documented. Yet, the underlying mechanism and the mode of inheritance have not been …
documented. Yet, the underlying mechanism and the mode of inheritance have not been …
Sperm epigenetic clock associates with pregnancy outcomes in the general population
JR Pilsner, H Saddiki, BW Whitcomb… - Human …, 2022 - academic.oup.com
STUDY QUESTION Is sperm epigenetic aging (SEA) associated with probability of
pregnancy among couples in the general population? SUMMARY ANSWER We observed a …
pregnancy among couples in the general population? SUMMARY ANSWER We observed a …
Spermatozoa from infertile patients exhibit differences of DNA methylation associated with spermatogenesis-related processes: an array-based analysis
C Camprubí, A Salas-Huetos, R Aiese-Cigliano… - Reproductive …, 2016 - Elsevier
The influence of aberrant sperm DNA methylation on the reproductive capacity of couples
has been postulated as a cause of infertility. This study compared the DNA methylation of …
has been postulated as a cause of infertility. This study compared the DNA methylation of …
Age-related sperm DNA methylation changes are transmitted to offspring and associated with abnormal behavior and dysregulated gene expression
MH Milekic, Y Xin, A O'donnell, KK Kumar… - Molecular …, 2015 - nature.com
Advanced paternal age (APA) has been shown to be a significant risk factor in the offspring
for neurodevelopmental psychiatric disorders, such as schizophrenia and autism spectrum …
for neurodevelopmental psychiatric disorders, such as schizophrenia and autism spectrum …
The DNA methylome of human sperm is distinct from blood with little evidence for tissue-consistent obesity associations
F Åsenius, TJ Gorrie-Stone, A Brew… - PLoS …, 2020 - journals.plos.org
Epidemiological research suggests that paternal obesity may increase the risk of fathering
small for gestational age offspring. Studies in non-human mammals indicate that such …
small for gestational age offspring. Studies in non-human mammals indicate that such …
Comparative whole genome DNA methylation profiling of cattle sperm and somatic tissues reveals striking hypomethylated patterns in sperm
Background Although sperm DNA methylation has been studied in humans and other
species, its status in cattle is largely unknown. Results Using whole-genome bisulfite …
species, its status in cattle is largely unknown. Results Using whole-genome bisulfite …
Broad DNA methylation changes of spermatogenesis, inflammation and immune response‐related genes in a subgroup of sperm samples for assisted reproduction
B Schütte, N El Hajj, J Kuhtz, I Nanda, J Gromoll… - …, 2013 - Wiley Online Library
Aberrant sperm DNA methylation patterns, mainly in imprinted genes, have been associated
with male subfertility and oligospermia. Here, we performed a genome‐wide methylation …
with male subfertility and oligospermia. Here, we performed a genome‐wide methylation …
Integrative DNA methylation and gene expression analyses identify DNA packaging and epigenetic regulatory genes associated with low motility sperm
SE Pacheco, EA Houseman, BC Christensen… - PloS one, 2011 - journals.plos.org
Background In previous studies using candidate gene approaches, low sperm count
(oligospermia) has been associated with altered sperm mRNA content and DNA methylation …
(oligospermia) has been associated with altered sperm mRNA content and DNA methylation …
Customized MethylC-capture sequencing to evaluate variation in the human sperm DNA methylome representative of altered folate metabolism
Background: The sperm DNA methylation landscape is unique and critical for offspring
health. If gamete-derived DNA methylation escapes reprograming in early embryos …
health. If gamete-derived DNA methylation escapes reprograming in early embryos …