Lycopene binds PDGF-BB and inhibits PDGF-BB-induced intracellular signaling transduction pathway in rat smooth muscle cells
Cardiovascular diseases (CVDs) result from the sub-endothelial accumulation of
inflammatory cells and smooth muscle cells (SMCs). Lycopene, a natural compound from …
inflammatory cells and smooth muscle cells (SMCs). Lycopene, a natural compound from …
Lycopene binding compromised PDGF-AA/-AB signaling and migration in smooth muscle cells and fibroblasts: prediction of the possible lycopene binding site within …
CP Chen, CF Hung, SC Lee, HM Lo, PH Wu… - … archives of pharmacology, 2010 - Springer
Platelet-derived growth factor (PDGF) is a potent stimulator of growth and motility of smooth
muscle cells (SMCs) and fibroblasts. Abnormalities of PDGF/PDGF receptor (PDGFR) are …
muscle cells (SMCs) and fibroblasts. Abnormalities of PDGF/PDGF receptor (PDGFR) are …
A naturally occurring carotenoid, lutein, reduces PDGF and H2O2 signaling and compromises migration in cultured vascular smooth muscle cells
HM Lo, YJ Tsai, WY Du, CJ Tsou, WB Wu - Journal of biomedical Science, 2012 - Springer
Background Platelet-derived growth factor (PDGF) is a potent stimulator of growth and
motility of vascular smooth muscle cells (VSMCs). Abnormalities of PDGF/PDGF receptor …
motility of vascular smooth muscle cells (VSMCs). Abnormalities of PDGF/PDGF receptor …
Luteolin prevents PDGF-BB-induced proliferation of vascular smooth muscle cells by inhibition of PDGF β-receptor phosphorylation
JH Kim, YR Jin, BS Park, TJ Kim, SY Kim, Y Lim… - Biochemical …, 2005 - Elsevier
Luteolin occurs as glycosylated forms in celery, green pepper, perilla leaf and camomile tea,
and has been shown to possess antimutagenic, antitumorigenic, antioxidant and …
and has been shown to possess antimutagenic, antitumorigenic, antioxidant and …
Mitogenesis of Vascular Smooth Muscle Cell Stimulated by Platelet‐Derived Growth Factor‐bb Is Inhibited by Blocking of Intracellular Signaling by Epigallocatechin‐3 …
MH Lee, BJ Kwon, MA Koo, KE You… - Oxidative medicine and …, 2013 - Wiley Online Library
Epigallocatechin gallate (EGCG) is known to exhibit antioxidant, antiproliferative, and
antithrombogenic effects and reduce the risk of cardiovascular diseases. Key events in the …
antithrombogenic effects and reduce the risk of cardiovascular diseases. Key events in the …
An inhibitory effect of chrysoeriol on platelet-derived growth factor (PDGF)-induced proliferation and PDGF receptor signaling in human aortic smooth muscle cells
BY Cha, WL Shi, T Yonezawa, T Teruya… - Journal of …, 2009 - jstage.jst.go.jp
Platelet-derived growth factor (PDGF)-BB is one of the most potent factors in the
development and progression of various vascular disorders such as restenosis and …
development and progression of various vascular disorders such as restenosis and …
Inhibition of PDGF beta-receptor tyrosine phosphorylation and its downstream intracellular signal transduction in rat aortic vascular smooth muscle cells by kaempferol
SY Kim, YR Jin, Y Lim, JH Kim, MR Cho… - Planta …, 2005 - thieme-connect.com
Kaempferol, a flavonoid present in human diet and plants, has been known to show
cardiovascular protection via its anti-oxidant activity. In this study, we have investigated the …
cardiovascular protection via its anti-oxidant activity. In this study, we have investigated the …
Pelargonidin attenuates PDGF-BB-induced aortic smooth muscle cell proliferation and migration by direct inhibition of focal adhesion kinase
Pelargonidin is a natural red pigment found in fruits and vegetables, and has been reported
to exhibit various effects potentially beneficial for human health. However, the possible …
to exhibit various effects potentially beneficial for human health. However, the possible …
The isoflavone metabolite cis-tetrahydrodaidzein inhibits ERK-1 activation and proliferation in human vascular smooth muscle cells
S Ling, A Dai, MRI Williams, AJ Husband… - Journal of …, 2004 - journals.lww.com
Phytoestrogens have recently been proposed as alternatives to estrogens for cardiovascular
protection; however, the effect of their metabolites on vascular biology is unclear. We studied …
protection; however, the effect of their metabolites on vascular biology is unclear. We studied …
Phosphoinositide 3-kinase is a novel target of piceatannol for inhibiting PDGF-BB-induced proliferation and migration in human aortic smooth muscle cells
Aims Abnormal migration and proliferation of human aortic smooth muscle cells (HASMCs)
to the intima causes intimal thickening of the aorta, which is strongly related to the …
to the intima causes intimal thickening of the aorta, which is strongly related to the …