Multiple developmental roles of VEGF suggested by a LacZ-tagged allele

L Miquerol, M Gertsenstein, K Harpal, J Rossant… - Developmental …, 1999 - Elsevier
Vascular endothelial growth factor (VEGF) is an angiogenic factor and a potent stimulator of
microvascular permeability. It is a mitogen specific for endothelial cells. The expression of …

VEGF regulates cell behavior during vasculogenesis

CJ Drake, A LaRue, N Ferrara, CD Little - Developmental biology, 2000 - Elsevier
Prominent among molecules that control neovascular processes is vascular endothelial
growth factor (VEGF). The VEGF ligands comprise a family of well-studied …

Regulation of flt‐1 expression during mouse embryogenesis suggests a role in the establishment of vascular endothelium

GH Fong, J Klingensmith, CR Wood… - Developmental …, 1996 - Wiley Online Library
Flt‐1 is a high affinity binding receptor for the vascular endothelial cell growth factor (VEGF)
and is primarily expressed in endothelial cells. In this study we have investigated the …

Differential expression of VEGF isoforms in mouse during development and in the adult

YS Ng, R Rohan, ME Sunday… - … dynamics: an official …, 2001 - Wiley Online Library
Vascular endothelial growth factor (VEGF), a factor that is critical for development of the
vascular system in mouse embryos, exists as at least three isoforms, VEGF120, VEGF164 …

A comparative study of the expression patterns for vegf, vegf-b/vrf and vegf-c in the developing and adult mouse

J Lagercrantz, F Farnebo, C Larsson, T Tvrdik… - … et Biophysica Acta (BBA …, 1998 - Elsevier
With the goal of better understanding the function and regulation of the different members of
the VEGF family this study reports mapping of vegf, vegf-b and vegf-c mRNA expression in …

Coordinate expression of vascular endothelial growth factor receptor‐1 (fit‐1) and its ligand suggests a paracrine regulation of murine vascular development

G Breier, M Clauss, W Risau - Developmental Dynamics, 1995 - Wiley Online Library
Vascular endothelial growth factor (VEGF) is a candidate regulator of blood vessel growth
during embryonic development and in tumors. To evaluate the role of VEGF receptor‐1/flt‐1 …

Vascular endothelial growth factor (VEGF) and VEGF receptor 2 (flk-1) are expressed during vasculogenesis and vascular differentiation in the quail embryo

I Flamme, G Breier, W Risau - Developmental biology, 1995 - Elsevier
Vasculogenesis, the de novo formation of embryonic blood vessels from their angioblastic
precursors in situ, is supposed to be under the control of polypeptide growth factors and their …

Localization of VEGF‐B in the mouse embryo suggests a paracrine role of the growth factor in the developing vasculature

K Aase, A Lymboussaki, A Kaipainen… - … dynamics: an official …, 1999 - Wiley Online Library
Vascular endothelial growth factor B (VEGF‐B) is structurally closely related to VEGF and
binds one of its receptors, VEGFR‐1. In situ hybridization and immunohistochemistry were …

Growing and shaping the vascular tree: multiple roles for VEGF

C Ruhrberg - Bioessays, 2003 - Wiley Online Library
Abstract Vascular Endothelial Growth Factor (VEGF) is the most potent and ubiquitous
vascular growth factor known to date. Yet, prior to its description as a secreted mitogen for …

Characterization of the endothelium-specific murine vascular endothelial growth factor receptor-2 (Flk-1) promoter

V Rönicke, W Risau, G Breier - Circulation research, 1996 - Am Heart Assoc
Flk-1, a high-affinity signaling receptor for vascular endothelial growth factor (VEGF), is
strongly and specifically expressed on endothelial cells during embryonic development of …