The tumor form of pyruvate kinase M2 (PKM2) undergoes tyrosine phosphorylation and
gives rise to the Warburg effect. The Warburg effect defines a pro-oncogenic metabolism …

Abstract Pyruvate kinase M2 (PKM2) is a glycolytic enzyme that is expressed in cancer cells.
Its role in tumor metabolism is not definitively established, but investigators have suggested …

The Warburg effect describes a pro-oncogenic metabolism switch such that cancer cells take
up more glucose than normal tissue and favor incomplete oxidation of glucose even in the …

One hundred years ago, Otto Heinrich Warburg observed that postmitotic retinal cells are the
highest oxygen-consuming cells in the body. He compared these cells to actively growing …

Purpose: Like cancer cells, photoreceptor cells produce lactate aerobically, requiring lactate
dehydrogenase A (LDH-A). Cancer cells also use glycolytic intermediates for biosynthesis …

The Warburg Effect, or aerobic glycolysis, is one of the major metabolic alterations observed
in cancer. Hypothesized to increase a cell's proliferative capacity via regenerating NAD+ …

Cancer cells predominantly produce energy at a high rate of glycolysis even in aerobic
environment. It is termed as Warburg effect and is necessary for the tumorigenesis. Studies …

The origins and role of the Warburg effect have remained uncertain for many years. Two
recent studies demonstrate that an embryonic-and cancer-cell-specific isoform of the …

Aerobic glycolysis, known as the" Warburg effect”, is one of several hallmarks of cancer
cells. The conversion of phosphoenolpyruvate (PEP) to pyruvate can be down regulated by …

The majority of cancer cells maintain a high glycolytic activity and an increased lactate
production, even in a well oxygenated environment. This phenomenon is known as the …