The prevalence of a return of depressive symptoms during maintenance AD treatment was 9–
57% in published trials [6], pointing to an occurrence of tolerance phenomena during AD …

BackgroundAntidepressant drugs are usually prescribed at low doses, possibly to avoid
adverse reactions. No comprehensive review has addressed the issue of dose, clinical …

Antidepressants, in particular newer agents, are among the most widely prescribed
medications worldwide with annual sales of billions of dollars. The introduction of these …

This article reviews how data on the benefits and hazards of antidepressants have been
analysed, and how conclusions drawn from these analyses conflict with the data …

A recent meta-analysis of antidepressant trials is the largest conducted to date. Although it
claims to prove antidepressant effectiveness beyond dispute, the main outcome is response …

Newer generation antidepressant drugs (ADs) are widely used as the first line of treatment
for major depressive disorders and are considered to be safer than tricyclic agents. In this …

Background In current psychiatric practice, antidepressants are widely and with ever-
increasing frequency prescribed to patients. However, several scientific biases obfuscate …

A recent meta-analysis concluded that newer antidepressant drugs are equivalent to or no
better than placebos, a conclusion at some variance with their commonly judged clinical …

Major depressive disorders affect an estimated 23 million US adults per year. While
antidepressants are effective in improving the symptoms of depression, side effects are an …

Prescribing of antidepressant treatment (ADT) for major depressive disorder (MDD) has
increased in quantity and popularity over the last two decades. This is likely due to the …