Harnessing the innate and adaptive immune system for tissue repair and regeneration: Considering more than macrophages

LC Shanley, OR Mahon, DJ Kelly, A Dunne - Acta Biomaterialia, 2021 - Elsevier
Tissue healing and regeneration is a complex, choreographed, spatiotemporal process
involving a plethora of cell types, the activity of which is stringently regulated in order for …

[HTML][HTML] Promoting tissue regeneration by modulating the immune system

Z Julier, AJ Park, PS Briquez, MM Martino - Acta biomaterialia, 2017 - Elsevier
The immune system plays a central role in tissue repair and regeneration. Indeed, the
immune response to tissue injury is crucial in determining the speed and the outcome of the …

Key players in the immune response to biomaterial scaffolds for regenerative medicine

L Chung, DR Maestas Jr, F Housseau… - Advanced drug delivery …, 2017 - Elsevier
The compatibility of biomaterials is critical to their structural and biological function in
medical applications. The immune system is the first responder to tissue trauma and to a …

Monocytes and macrophages in tissue repair: Implications for immunoregenerative biomaterial design

ME Ogle, CE Segar, S Sridhar… - … Biology and Medicine, 2016 - journals.sagepub.com
Monocytes and macrophages play a critical role in tissue development, homeostasis, and
injury repair. These innate immune cells participate in guiding vascular remodeling …

Biomaterials-mediated regulation of macrophage cell fate

Y Liu, T Segura - Frontiers in bioengineering and biotechnology, 2020 - frontiersin.org
Endogenous regeneration aims to rebuild and reinstate tissue function through enlisting
natural self-repairing processes. Promoting endogenous regeneration by reducing tissue …

Macrophage phenotypes in tissue repair and the foreign body response: Implications for biomaterial-based regenerative medicine strategies

KE Martin, AJ García - Acta biomaterialia, 2021 - Elsevier
Macrophages are a highly heterogeneous and plastic population of cells that are crucial for
tissue repair and regeneration. This has made macrophages a particularly attractive target …

Applications of biomaterials for immunosuppression in tissue repair and regeneration

P Shen, Y Chen, S Luo, Z Fan, J Wang, J Chang… - Acta Biomaterialia, 2021 - Elsevier
The immune system plays an essential role in tissue repair and regeneration. Regardless of
innate or adaptive immune responses, immunosuppressive strategies such as macrophage …

The role of biomaterials and scaffolds in immune responses in regenerative medicine: macrophage phenotype modulation by biomaterial properties and scaffold …

E Antmen, NE Vrana, V Hasirci - Biomaterials science, 2021 - pubs.rsc.org
Scaffolds are an integral part of the regenerative medicine field. The contact of biomaterials
with tissue, as was clearly observed over the years, induces immune reactions in a material …

Divergent immune responses to synthetic and biological scaffolds

K Sadtler, MT Wolf, S Ganguly, CA Moad, L Chung… - Biomaterials, 2019 - Elsevier
The immune system plays a critical role in wound healing and the response to biomaterials.
Biomaterials-directed regenerative immunology is an immunoengineering strategy that …

T lymphocytes as critical mediators in tissue regeneration, fibrosis, and the foreign body response

KM Adusei, TB Ngo, K Sadtler - Acta Biomaterialia, 2021 - Elsevier
Research on the foreign body response (FBR) to biomaterial implants has been focused on
the roles that the innate immune system has on mediating tolerance or rejection of implants …