Bacterial superantigens are small proteins that have a very potent stimulatory effect on T
lymphocytes through their ability to bind to both MHC class II molecules and T-cell receptors …

Streptococcal superantigen (SSA) is a 28,000 M r toxin originally isolated from a pathogenic
strain of Streptococcus pyogenes that has 60% sequence identity with staphylococcal …

MHC class II molecules possess two binding sites for bacterial superantigens (SAGs): a low-
affinity site on the α chain and a high-affinity, zinc-dependent site on the β chain. Only the …

Staphylococcal enterotoxin B is a member of a family of toxins known as superantigens that
activate a large number of T-cells (up to 20%) by cross-linking MHC class II molecules with T …

Superantigens (SAgs) are potent microbial toxins that bind simultaneously to T cell receptors
(TCRs) and class II major histocompatibility complex molecules, resulting in the activation …

SUPERANTIGENS stimulate T cells bearing particular T-cell receptor Vβ sequences1, 2, so
they are extremely potent polyclonal T-cell mitogens. T-cell activation is preceded by binding …

SUPERANTIGENS (SAgs) are viral or bacterial proteins that act as potent T-cell stimulants
and have been implicated in a number of human diseases, including toxic shock …

Superantigens (SAGs) are a class of immunostimulatory proteins of bacterial or viral origin
that activate T cells by binding to the Vβ domain of the T cell antigen receptor (TCR). The …

Superantigens are bacterial or viral proteins that elicit massive T cell activation through
simultaneous binding to major histocompatibility complex (MHC) class II and T cell …

Recombinant streptococcal pyrogenic exotoxin C (SPE-C) is a potent superantigen that
stimulates Vβ2-bearing human T cells, but is inactive in mice. SPE-C binds with high affinity …