Inflammatory bowel disease: between genetics and microbiota

N Younis, R Zarif, R Mahfouz - Molecular biology reports, 2020 - Springer
Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disease that can
involve any part of the gastrointestinal tract. It includes two main disorders: Crohn's disease …

The genetic background of inflammatory bowel disease: from correlation to causality

WTC Uniken Venema, MD Voskuil… - The Journal of …, 2017 - Wiley Online Library
Recent studies have greatly improved our insight into the genetic background of
inflammatory bowel disease (IBD). New high‐throughput technologies and large‐scale …

Inflammatory bowel disease: genetics, epigenetics, and pathogenesis

I Loddo, C Romano - Frontiers in immunology, 2015 - frontiersin.org
Inflammatory bowel diseases (IBDs) are complex, multifactorial disorders characterized by
chronic relapsing intestinal inflammation. Although etiology remains largely unknown, recent …

Association among genetic predisposition, gut microbiota, and host immune response in the etiopathogenesis of inflammatory bowel disease

PJ Basso, MTC Fonseca, G Bonfá… - Brazilian Journal of …, 2014 - SciELO Brasil
Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative
colitis (UC), is a chronic disorder that affects thousands of people around the world. These …

Determinants of IBD heritability: genes, bugs, and more

W Turpin, A Goethel, L Bedrani… - Inflammatory bowel …, 2018 - academic.oup.com
Defining the etiology of inflammatory bowel disease (IBD) continues to elude researchers, in
part due to the possibility that there may be different triggers for a spectrum of disease …

New frontiers in genetics, gut microbiota, and immunity: a rosetta stone for the pathogenesis of inflammatory bowel disease

M Zhou, J He, Y Shen, C Zhang… - BioMed research …, 2017 - Wiley Online Library
Inflammatory bowel disease (IBD), which encompasses ulcerative colitis (UC) and Crohn's
disease (CD), is a complicated, uncontrolled, and multifactorial disorder characterized by …

Molecular pathogenesis of inflammatory bowel disease: genotypes, phenotypes and personalized medicine

P Goyette, C Labbé, TT Trinh, RJ Xavier… - Annals of …, 2007 - Taylor & Francis
Crohn's disease (CD) and ulcerative colitis (UC), also known as inflammatory bowel
diseases (IBD), are characterized by chronic inflammation of the gastrointestinal tract. IBD is …

Redefining the IBDs using genome-scale molecular phenotyping

TS Furey, P Sethupathy, SZ Sheikh - Nature reviews Gastroenterology & …, 2019 - nature.com
Abstract The IBDs, Crohn's disease and ulcerative colitis, are chronic inflammatory
conditions of the gastrointestinal tract resulting from an aberrant immune response to enteric …

Genetics and environmental interactions shape the intestinal microbiome to promote inflammatory bowel disease versus mucosal homeostasis

RB Sartor - Gastroenterology, 2010 - gastrojournal.org
Recent genome-wide genetic association studies and advances in molecular analysis of
microbial composition have improved dramatically our understanding of the pathogenesis of …

Beyond gene discovery in inflammatory bowel disease: the emerging role of epigenetics

NT Ventham, NA Kennedy, ER Nimmo, J Satsangi - Gastroenterology, 2013 - Elsevier
In the past decade, there have been fundamental advances in our understanding of genetic
factors that contribute to the inflammatory bowel diseases (IBDs) Crohn's disease and …