After spinal cord injury (SCI) in mammals, severed axons fail to regenerate, due to both
extrinsic inhibitory factors, eg, the chondroitin sulfate proteoglycans (CSPGs) and myelin …

Paralysis following spinal cord injury (SCI) is due to interruption of axons and their failure to
regenerate. It has been suggested that the small GTPase RhoA may be an intracellular …

Paralysis following spinal cord injury (SCI) is due to failure of axonal regeneration. It is
believed that the capacities of neurons to regrow their axons are due partly to their intrinsic …

The regeneration of adult peripheral neurons after transection is slow, incomplete and
encumbered by severe barriers to proper regrowth. The role of RHOA GTPase has not been …

Inhibition of the small GTPase ras homology protein (Rho) or its downstream target, the Rho‐
associated kinase (ROCK), has been shown to promote axon regeneration and to improve …

Axonal regeneration in the central nervous system is blocked by many different growth
inhibitory factors. Some of these inhibitors act on neurons by activating RhoA and Rho …

Objective To quantitatively analyze the temporal and spatial pattern of RhoA expression in
injured spinal cord of adult mice. Methods A spinal cord transection model was established …

Limited axonal plasticity within the central nervous system (CNS) is a major restriction for
functional recovery after CNS injury. The small GTPase RhoA is a key molecule of the …

Previously, we reported that RhoA knockdown by morpholino antisense oligonucleotides
(MOs), and enzymatic digestion of chondroitin sulfate proteoglycans (CSPGs) at the site of …

Growth inhibitory proteins in the central nervous system (CNS) block axon growth and
regeneration by signaling to Rho, an intracellular GTPase. It is not known how CNS trauma …