Nonsteroidal anti-inflammatory drugs (NSAIDs) are extensively used to relieve pain and
inflammation in humans via cyclooxygenase inhibition. Our recent research suggests that …

Regeneration is bungled following CNS injuries, including spinal cord injury (SCI). Inherent
decay of permissive conditions restricts the regrowth of the mature CNS after an injury …

Publisher Summary This chapter discusses the inactivation of intracellular Rho to stimulate
axon growth and regeneration. In tissue culture, inactivation of the Rho signaling pathway is …

Inhibition of the small GTPase RhoA or its downstream target Rho‐associated coiled kinase
(ROCK) has been shown to promote axon regeneration and to improve functional recovery …

In injured adult neurons, the process of axonal regrowth and reestablishment of the
neuronal function have to be activated. We assessed in this study whether RhoA, a key …

Rho is an important signaling target to promote repair following spinal cord injury (SCI).
Myelinderived inhibitory proteins, as well as other classes of known growth inhibitory …

Inhibition of RhoA has been shown to enhance axonal regeneration following spinal cord
injury. Here we mapped mRNA expression patterns of RhoA, B, and C, Rac1, Cdc42, and …

Local axon degeneration is a common pathological feature of many neurodegenerative
diseases, whereas the underlying molecular mechanisms are largely unknown. In this study …

It is currently thought that treatment for spinal cord injury (SCI) will involve a combined
pharmacological and biological approach; however, testing their efficacy in animal models …

An inhibitory extracellular milieu and neuron-intrinsic processes prevent axons from
regenerating in the adult central nervous system (CNS). Here we show how the two aspects …