Novel therapeutic targets for prevention and therapy of sepsis associated acute kidney injury

CH Pelte, LS Chawla - Current drug targets, 2009 - ingentaconnect.com
Sepsis associated Acute Kidney Injury (SA-AKI) is the leading cause of AKI in the hospital
setting and its incidence is increasing. Although the exact pathophysiology and phenotype …

Update on sepsis-associated acute kidney injury: emerging targeted therapies

JF Doyle, LG Forni - Biologics: Targets and Therapy, 2016 - Taylor & Francis
Sepsis-associated acute kidney injury (SA-AKI) is an independent predictor of increased
mortality and morbidity. It is essential that further advances in the treatment of sepsis should …

Emerging therapeutic targets of sepsis-associated acute kidney injury

S Swaminathan, MH Rosner, MD Okusa - Seminars in nephrology, 2015 - Elsevier
Sepsis-associated acute kidney injury (SA-AKI) is linked to high morbidity and mortality. To
date, singular approaches to target specific pathways known to contribute to the …

[HTML][HTML] Acute kidney injury from sepsis: current concepts, epidemiology, pathophysiology, prevention and treatment

S Peerapornratana, CL Manrique-Caballero… - Kidney international, 2019 - Elsevier
Sepsis-associated acute kidney injury (S-AKI) is a frequent complication of the critically ill
patient and is associated with unacceptable morbidity and mortality. Prevention of S-AKI is …

Sepsis and acute kidney injury: a review focusing on the bidirectional interplay

YM Chang, YT Chou, WC Kan, CC Shiao - International Journal of …, 2022 - mdpi.com
Although sepsis and acute kidney injury (AKI) have a bidirectional interplay, the
pathophysiological mechanisms between AKI and sepsis are not clarified and worthy of a …

Septic acute kidney injury: molecular mechanisms and the importance of stratification and targeting therapy

ED Morrell, JA Kellum, NM Pastor-Soler, KR Hallows - Critical care, 2014 - Springer
The most common cause of acute kidney injury (AKI) in hospitalized patients is sepsis.
However, the molecular pathways and mechanisms that mediate septic AKI are not well …

Recent advances in the pathogenetic mechanisms of sepsis-associated acute kidney injury

F Fani, G Regolisti, M Delsante, V Cantaluppi… - Journal of …, 2018 - Springer
Sepsis is a serious medical condition that can lead to multi-organ failure and shock, and it is
associated with increased mortality. Acute kidney injury (AKI) is a frequent complication of …

Sepsis-associated acute kidney injury

CL Manrique-Caballero… - Critical Care …, 2021 - criticalcare.theclinics.com
Sepsis-associated acute kidney injury (S-AKI) is a common, life-threatening complication in
hospitalized and critically ill patients. S-AKI increases in-hospital mortality 6-fold to 8-fold, 1 …

[HTML][HTML] Immunoregulatory mechanism of acute kidney injury in sepsis: a narrative review

S Sun, R Chen, X Dou, M Dai, J Long, Y Wu… - Biomedicine & …, 2023 - Elsevier
Sepsis acute kidney injury (SAKI) is a common complication of sepsis, accounting for 26–
50% of all acute kidney injury (AKI). AKI is an independent risk factor for increased mortality …

Sepsis-associated acute kidney injury—treatment standard

A Zarbock, JL Koyner, H Gomez… - Nephrology Dialysis …, 2024 - academic.oup.com
Sepsis is a host's deleterious response to infection, which could lead to life-threatening
organ dysfunction. Sepsis-associated acute kidney injury (SA-AKI) is the most frequent …