In response to progressive telomere shortening in successive cell divisions, normal somatic
cells enter senescence, during which they cease to proliferate irreversibly and undergo …

Senescence is regarded as a physiological response of cells to stress, including telomere
dysfunction, aberrant oncogenic activation, DNA damage, and oxidative stress. This stress …

Normal cells do not divide indefinitely due to a process termed cellular or replicative
senescence. Several lines of evidence suggest that replicative senescence evolved to …

Cellular senescence entails a state of an essentially irreversible proliferative arrest in which
cells remain metabolically active and secrete a range of pro-inflammatory and proteolytic …

Normal cells, with few exceptions, cannot proliferate indefinitely. Cell populations—in vivo
and in culture—generally undergo only a limited number of doublings before proliferation …

Historically, the senescent state has been associated with, and was named after, the cell-
cycle arrest that occurs after cells have undergone an intrinsically defined number of …

Cellular senescence is an irreversible arrest of proliferation. It is activated when a cell
encounters stress such as DNA damage, telomere shortening or oncogene activation. Like …

Cellular senescence is recognized as a critical cellular response to prolonged rounds of
replication and environmental stresses. Its defining characteristics are arrested cell-cycle …

Cellular senescence is a signal transduction program leading to irreversible cell cycle arrest.
This growth arrest can be triggered by many different mechanisms including recognition by …

Cellular senescence is an important mechanism for preventing the proliferation of potential
cancer cells. Recently, however, it has become apparent that this process entails more than …