The immune system can both promote and constrain cancer development. Chronic
inflammatory conditions predispose to cancer formation in multiple organs, highlighting the …

Chemokines are important components of cancer-related inflammation. In this issue of
Cancer Cell, Chen et al. report that the chemokine CCL18, produced by tumor-associated …

T cells play a critical role in tumor immunosurveillance by eliminating newly transformed
somatic cells. However, tumor cell variants can escape from immunological control after …

Viral infection triggers innate immune signaling, which in turn induces interferon‐β (IFN‐β)
production to establish innate antiviral immunity. Previous studies showed that Gcn5 …

Inflammation is a well-known driver of lung tumorigenesis. One strategy by which tumor cells
escape tight homeostatic control is by decreasing the expression of the potent anti …

Introduction Suppression of dendritic cells (DCs) is a crucial mechanism by which tumor
cells escape immune recognition and elimination. We have recently reported that MHC class …

Macrophages and neutrophils are phagocytes that play major roles in the onset and
maintenance of many diseases. These two cell types that belong to the innate immune …

Adenosine triphosphate (ATP) is actively released in the extracellular environment in
response to tissue damage and cellular stress. Through the activation of P2X and P2Y …

Tumor associated macrophage responses are regulated by distinct metabolic states that
affect their function. However, the ability of specific signals in the local tumor …

The innate immune response involves a variety of inflammatory reactions that can result in
inflammatory disease and cancer if they are not resolved and instead are allowed to persist …