The epidermal growth factor receptor (EGFR) is overexpressed in the majority of non–small
cell lung cancers (NSCLC). EGFR tyrosine kinase inhibitors, such as gefitinib and erlotinib …

Background The epidermal growth-factor receptor tyrosine kinase inhibitors have been
effective in non-small cell lung cancer patients. However, acquired resistance eventually …

Significant improvements in the outcome of non–small cell lung carcinoma (NSCLC) have
been reported in patients treated with the epidermal growth factor receptor (EGFR) inhibitor …

Abstract Treatment of second-and third-line patients with non–small-cell lung carcinoma
(NSCLC) with the epidermal growth factor receptor (EGFR) kinase inhibitor erlotinib …

Aberrant activation of the hedgehog (Hh) signaling pathway has been implicated in the
epithelial-to-mesenchymal transition (EMT) and cancer stem-like cell (CSC) maintenance; …

Abstract E-cadherin (E-cad) and epidermal growth factor receptor (EGFR) are important cell
adhesion and signaling pathway mediators. This study aimed to assess their expression in …

E-cadherin loss in cancer is associated with de-differentiation, invasion, and metastasis.
Drosophila DE-cadherin is regulated by Wnt/β-catenin signaling, although this has not been …

The modest response of patients with head and neck squamous cell carcinoma (HNSCC)
and non–small cell lung carcinoma (NSCLC) to epithelial growth factor receptor tyrosine …

PURPOSE: E-cadherin (E-cad) and its associated intracellular molecules, catenins, are
critical for intercellular epithelial adhesion and are often expressed in non–small-cell lung …

E-cadherin is a calcium-dependent, epithelial cell adhesion molecule whose reduced
expression has been associated with tumor dedifferentiation and increased lymph node …