IQGAP1 enhances cell invasion and matrix metalloproteinase-2 expression through upregulating NF-κB activity in esophageal squamous cell carcinoma cells
Z Zhang, Y Wei, X Li, R Zhao, X Wang, Z Yang, T Li… - Gene, 2022 - Elsevier
Esophageal squamous cell carcinoma (ESCC) is one type of the most common
malignancies, yet the overall survival rate is still not ideal. IQ motif containing GTPase …
malignancies, yet the overall survival rate is still not ideal. IQ motif containing GTPase …
[HTML][HTML] Targeted Knockdown of IQGAP1 Inhibits the Progression of Esophageal Squamous Cell Carcinoma In Vitro and In Vivo
XX Wang, K Wang, XZ Li, LQ Zhai, CX Qu, Y Zhao… - PLoS …, 2014 - journals.plos.org
IQGAP1 is a scaffolding protein that can regulate several distinct signaling pathways. The
accumulating evidence has demonstrated that IQGAP1 plays an important role in …
accumulating evidence has demonstrated that IQGAP1 plays an important role in …
IQGAP1 silencing suppresses the malignant characteristics of laryngeal squamous cell carcinoma cells
X Wang, C He, C Li, B Ren, Q Deng… - The International …, 2018 - journals.sagepub.com
Background: Laryngeal squamous cell carcinoma (LSCC) has a poor prognosis due to
recurrence and metastasis. IQ-domain GTPase-activating protein 1 (IQGAP1), a scaffold …
recurrence and metastasis. IQ-domain GTPase-activating protein 1 (IQGAP1), a scaffold …
Over-expression of IQGAP1 indicates poor prognosis in head and neck squamous cell carcinoma
CC Wu, H Li, Y Xiao, LL Yang, L Chen… - Journal of Molecular …, 2018 - Springer
IQ-domain GTPase-activating protein 1 (IQGAP1) is associated with the development and
progression of many human cancers. We aimed to investigate the expression and …
progression of many human cancers. We aimed to investigate the expression and …
Downregulation of IQGAP1 inhibits epithelial‐mesenchymal transition via the HIF1α/VEGF‐A signaling pathway in gastric cancer
J Liu, X Ni, Y Li, M Chen, W Chen, Y Wu… - Journal of Cellular …, 2019 - Wiley Online Library
As an oncogene, IQ‐domain GTPase‐activating protein 1 (IQGAP1) regulates the epithelial‐
mesenchymal transition (EMT) of several cancers, such as breast cancer, thyroid cancer …
mesenchymal transition (EMT) of several cancers, such as breast cancer, thyroid cancer …
[HTML][HTML] Overexpression of IQGAP1 promotes the angiogenesis of esophageal squamous cell carcinoma through the AKT and ERK‑mediated VEGF‑VEGFR2 …
CH Li, XJ Sun, SS Niu, CY Yang… - Oncology …, 2018 - spandidos-publications.com
Angiogenesis is crucial for the progression of esophageal squamous cell carcinoma
(ESCC). Anti‑angiogenesis by targeting important molecules has been considered as one of …
(ESCC). Anti‑angiogenesis by targeting important molecules has been considered as one of …
[HTML][HTML] Overexpression and biological function of IQGAP3 in human pancreatic cancer
W Xu, B Xu, Y Yao, X Yu, H Cao, J Zhang… - American journal of …, 2016 - ncbi.nlm.nih.gov
IQGAP3 (IQ motif containing GTPase activating protein3) belongs to IQGAP family. Recent
studies have investigated that IQGAP3 was overexpressed in several tumor tissues. This …
studies have investigated that IQGAP3 was overexpressed in several tumor tissues. This …
High expression of IQGAP3 indicates poor prognosis in colorectal cancer patients
J Wu, Z Chen, H Cao, Z Yu, J Feng… - … journal of biological …, 2019 - journals.sagepub.com
Background: The oncogene IQ motif-containing GTPase activating protein 3 (IQGAP3) is
ubiquitously overexpressed in several human cancers. This study was designed to explore …
ubiquitously overexpressed in several human cancers. This study was designed to explore …
[HTML][HTML] Role of IQGAP3 in metastasis and epithelial–mesenchymal transition in human hepatocellular carcinoma
Y Shi, N Qin, Q Zhou, Y Chen, S Huang, B Chen… - Journal of translational …, 2017 - Springer
Background Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide
owing to its high rates of metastasis and recurrence. The oncogene IQ motif-containing …
owing to its high rates of metastasis and recurrence. The oncogene IQ motif-containing …
[HTML][HTML] IQGAP1 expression in hepatocellular carcinoma predicts poor prognosis by inducing epithelial-mesenchymal transition
C Li, TF Wen, XY Zhang, X Chen… - Translational Cancer …, 2017 - tcr.amegroups.org
Background: The prognostic value of expression of the IQ motif containing GTPase
activating protein 1 (IQGAP1) in hepatocellular carcinoma (HCC) following liver resection …
activating protein 1 (IQGAP1) in hepatocellular carcinoma (HCC) following liver resection …