Chronic alcohol consumption promotes diethylnitrosamine-induced hepatocarcinogenesis via immune disturbances

G Yan, X Wang, C Sun, X Zheng, H Wei, Z Tian… - Scientific reports, 2017 - nature.com
Chronic alcohol consumption increases the risk of hepatocellular carcinoma (HCC).
However, little is known about the potential immunological mechanisms by which ethanol …

Chronic ethanol feeding accelerates hepatocellular carcinoma progression in a sex‐dependent manner in a mouse model of hepatocarcinogenesis

E Brandon‐Warner, TL Walling… - Alcoholism: Clinical …, 2012 - Wiley Online Library
Background: Chronic ethanol consumption increases the risk of hepatic cirrhosis and
hepatocellular carcinoma (HCC). While sex differences exist in susceptibility to ethanol …

Alcohol consumption promotes diethylnitrosamine-induced hepatocarcinogenesis in male mice through activation of the Wnt/β-catenin signaling pathway

KE Mercer, L Hennings, N Sharma, K Lai… - Cancer Prevention …, 2014 - AACR
Although alcohol effects within the liver have been extensively studied, the complex
mechanisms by which alcohol causes liver cancer are not well understood. It has been …

Alcoholic hepatitis accelerates early hepatobiliary cancer by increasing stemness and miR-122-mediated HIF-1α activation

A Ambade, A Satishchandran, G Szabo - Scientific reports, 2016 - nature.com
Alcohol-related hepatocellular carcinoma (HCC) develops with advanced alcoholic liver
disease and liver fibrosis. Using adult mice, we evaluate the effect of alcoholic …

A preclinical model of chronic alcohol consumption reveals increased metastatic seeding of colon cancer cells in the liver

HJ Im, HG Kim, JS Lee, HS Kim, JH Cho, IJ Jo, SJ Park… - Cancer Research, 2016 - AACR
Liver metastasis is the main cause of death from colorectal cancer. Alcohol consumption
impacts liver function and is suggested to be an independent risk factor for liver metastasis …

Chronic ingestion of ethanol induces hepatocellular carcinoma in mice without additional hepatic insult

M Tsuchishima, J George, H Shiroeda… - Digestive diseases and …, 2013 - Springer
Background Chronic intake of alcohol increases the risk of gastrointestinal and hepatic
carcinogenesis. The present study was focused to investigate the incidence and mechanism …

[HTML][HTML] Adult mouse model of early hepatocellular carcinoma promoted by alcoholic liver disease

A Ambade, A Satishchandran… - World journal of …, 2016 - ncbi.nlm.nih.gov
AIM: To establish a mouse model of alcohol-driven hepatocellular carcinoma (HCC) that
develops in livers with alcoholic liver disease (ALD). METHODS: Adult C57BL/6 male mice …

Maotai ameliorates diethylnitrosamine-initiated hepatocellular carcinoma formation in mice

X Yi, L Long, C Yang, Y Lu, M Cheng - PloS one, 2014 - journals.plos.org
Consumption of alcohol is closely related to liver disease, such as hepatic fibrosis or even
hepatocellular carcinoma (HCC). However, epidemiological and experimental studies …

Alcohol consumption, Wnt/β-catenin signaling, and hepatocarcinogenesis

KE Mercer, L Hennings, MJJ Ronis - Biological Basis of Alcohol-Induced …, 2015 - Springer
Alcohol is a well-established risk factor for hepatocellular carcinoma, and the mechanisms
by which alcohol liver cancer is complex. It has been suggested that ethanol (EtOH) …

High-fat diet promotes macrophage-mediated hepatic inflammation and aggravates diethylnitrosamine-induced hepatocarcinogenesis in mice

H Fu, B Tang, J Lang, Y Du, B Cao, L Jin, M Fang… - Frontiers in …, 2020 - frontiersin.org
It has been reported that diet and nutrition play important roles in the occurrence and
development of hepatocellular carcinoma (HCC). In this study, we investigated the potential …