The mechanism by which the individual odor signals are translated into the perception of
smell in the brain is unknown. The signal processing occurs in the olfactory system which …

This report defines the identity of a calcium-regulated membrane guanylate cyclase
transduction system in the cilia of olfactory sensory neurons, which is the site of odorant …

This review focuses on the principles of the Ca 2+-modulated ROS-GC subfamily
transduction system linked with the mammalian olfactory transduction field, its historical …

In a subset of olfactory epithelium the odorant receptor guanylate cyclase, ONE-GC, is a
central transduction component of the cyclic GMP signaling pathway. The odorant binds to …

In a subset of the olfactory sensory neurons ONE-GC $ membrane guanylate cyclase is a
central component of two odorant-dependent cyclic GMP signaling pathways. These …

The mammalian olfactory system recognizes a wide range of chemical stimuli. The majority
of cells in the main olfactory epithelium (MOE) use a cAMP‐mediated signaling system to …

Rod outer segment guanylate cyclase 1 (ROS-GC1) is a pivotal enzyme for vertebrate
phototransduction and the systematically growing evidence point to its connection with …

GC (guanylate cyclase)-G is the most recently identified member of the receptor GC family.
However, the regulation of its activity and protein expression in the mammalian olfactory …

Guanylyl cyclases (GCs) catalyze the conversion of GTP to the second messenger cGMP.
While some transmembrane GCs are receptors for extracellular ligands, other …

The second messengers cAMP and inositol-1, 4, 5-triphosphate have been implicated in
olfaction in various species. The odorant-induced cGMP response was investigated using …