BACKGROUND: Several assays have been developed to detect antibodies to aquaporin-4
(NMO-IgG/AQP4-Ab). However, many of these assays require sophisticated techniques and …

Aquaporin‐4 (AQP4) is a dominant water channel in the brain and is expressed on astrocytic
end‐feet, mediating water homeostasis in the brain. AQP4 is a target of an inflammatory …

A total of 66 samples (from 27 cases with neuromyelitis optica, 26 cases with multiple
sclerosis, and 13 cases with optic neuritis) were tested for aquaporin-4 antibody by a cell …

Background Neuromyelitis optica (NMO) is a demyelinating disease of the central nervous
system (CNS) of putative autoimmune aetiology. Early discrimination between multiple …

Since the seminal description by Sir Thomas Clifford Allbutt in Cambridge 1870 [1] and the
systematic review by Eugene Devic and his student Fernand Gault in Lyon 1894 [2] …

Abstract Aquaporin-4 (AQP4) is a water-selective transporter expressed in astrocytes
throughout the central nervous system, as well as in kidney, lung, stomach and skeletal …

There is considerable potential for translating knowledge of aquaporin structure, function
and physiology to the clinic. One area is in aquaporin-based diagnostics. The discovery of …

Neuromyelitis optica (NMO; also termed Devic's disease) is a severely disabling
autoimmune disorder of the central nervous system (CNS), which predominantly affects the …

NMO‐IgG autoantibody is now considered a useful serum biomarker of neuromyelitis optica
(NMO). A series of clinical and pathological observations suggest that NMO‐IgG may play a …

The astrocytic aquaporin-4 (AQP4) water channel is the target of pathogenic antibodies in a
spectrum of relapsing autoimmune inflammatory central nervous system disorders of varying …