Background The involvement of astrocyte water channel aquaporin-4 (AQP4) in
autoimmune diseases of the central nervous system has been suggested following the …

In up to 80% of patients, neuromyelitis optica (NMO, Devic's syndrome), is associated with
antibodies to aquaporin-4 (AQP4-Ab), the most abundant water channel in the central …

In 2004, Lennon et al.[7, 9] discovered a novel, pathogenic serum autoantibody reactivity
[termed neuromyelitis optica (NMO)-IgG]. Aquaporin-4 (AQP4), the target antigen of NMO …

Neuromyelitis optica (NMO) is a devastating neuroinflammatory disorder that specifically
targets the spinal cord and optic nerves. Aquaporin-4 (AQP4) is the target of the NMO-IgG …

Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune central nervous system
(CNS) inflammatory disorder that can lead to serious disability and mortality. Females are …

Autoantibodies against astrocyte water channel aquaporin-4 (AQP4) are highly specific for
the neuroinflammatory disease neuromyelitis optica (NMO). We measured the binding of …

Aquaporins (AQPs) represent a diverse family of membrane proteins found in prokaryotes
and eukaryotes. The primary aquaporins expressed in the mammalian brain are AQP1 …

Background: Antibodies to aquaporin-4 (AQP4-Ab), known as NMO-IgG, are a sensitive and
specific marker for neuromyelitis optica (NMO). Methods: To develop an enzyme-linked …

Neuromyelitis optica (NMO) is a severe, debilitating human disease that predominantly
features immunopathology in the optic nerves and the spinal cord. An IgG1 autoantibody …

Neuromyelitis optica (NMO) is associated with antibodies to aquaporin 4 (AQP4). We
hypothesized that antibodies to AQP4 can be triggered by exposure to environmental …