UiO-66 nanoparticles combat influenza A virus in mice by activating the RIG-I-like receptor signaling pathway

R Su, X Li, J Xiao, J Xu, J Tian, T Liu, Y Hu - Journal of Nanobiotechnology, 2024 - Springer
Abstract The Influenza A virus (IAV) is a zoonotic pathogen that infects humans and various
animal species. Infection with IAV can cause fever, anorexia, and dyspnea and is often …

Transcriptome profiling reveals differential effect of interleukin-17A upon influenza virus infection in human cells

J Li, K Zhang, W Fan, S Zhang, Y Li, J Gu… - Frontiers in …, 2019 - frontiersin.org
Influenza A virus (IAV) has developed elegant strategies to utilize cellular proteins and
pathways to promote replication and evade the host antiviral response. Identification of …

Virus-like particle–mediated delivery of the RIG-I agonist M8 induces a type I interferon response and protects cells against viral infection

E Palermo, M Alexandridi, D Di Carlo… - Frontiers in Cellular …, 2022 - frontiersin.org
Virus-Like Particles (VLPs) are nanostructures that share conformation and self-assembly
properties with viruses, but lack a viral genome and therefore the infectious capacity. In this …

Pre-treatment with zirconia nanoparticles reduces inflammation induced by the pathogenic H5N1 influenza virus

C Huo, J Xiao, K Xiao, S Zou, M Wang… - International journal …, 2020 - Taylor & Francis
Background New approaches are urgently needed to fight influenza viral infection. Previous
research has shown that zirconia nanoparticles can be used as anticancer materials, but …

Silver nanoparticle based codelivery of oseltamivir to inhibit the activity of the H1N1 influenza virus through ROS-mediated signaling pathways

Y Li, Z Lin, M Zhao, T Xu, C Wang, L Hua… - … applied materials & …, 2016 - ACS Publications
As the therapeutic agent for antiviral applications, the clinical use of oseltamivir is limited
with the appearance of drug-resistant viruses. It is important to explore novel anti-influenza …

Gold nanorod delivery of an ssRNA immune activator inhibits pandemic H1N1 influenza viral replication

KV Chakravarthy, AC Bonoiu… - Proceedings of the …, 2010 - National Acad Sciences
The emergence of the pandemic 2009 H1N1 influenza virus has become a world-wide
health concern. As drug resistance appears, a new generation of therapeutic strategies will …

Antiviral activity of influenza A virus defective interfering particles against SARS-CoV-2 replication in vitro through stimulation of innate immunity

U Rand, SY Kupke, H Shkarlet, MD Hein, T Hirsch… - Cells, 2021 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus
disease 2019 (COVID-19) emerged in late 2019 and resulted in a devastating pandemic …

Interleukin 16 enhances the host susceptibility to influenza A virus infection

R Jia, C Jiang, L Li, C Huang, L Lu, M Xu, J Xu… - Frontiers in …, 2021 - frontiersin.org
Influenza A virus (IAV) is a major respiratory pathogen that causes seasonal and pandemic
flu, being a threat to global health. Various viral and cellular factors have been characterized …

[HTML][HTML] Lidocaine inhibits influenza a virus replication by up-regulating IFNα4 via TBK1-IRF7 and JNK-AP1 signaling pathways

X Liu, F Zheng, L Tian, T Li, Z Zhang, Z Ren… - International …, 2023 - Elsevier
Influenza A viruses (IAV), significant respiratory pathogenic agents, cause seasonal
epidemics and global pandemics in intra-and interannual cycles. Despite effective therapies …

[HTML][HTML] Downregulation of miR-146a inhibits influenza A virus replication by enhancing the type I interferon response in vitro and in vivo

F Zhang, X Sun, Y Zhu, W Qin - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Albeit microRNAs (miRNAs) have become increasingly appreciated for their essential roles
in innate immune responses to viral infections; however, it is unknown how host miRNAs …