Mechanisms underlying interferon-mediated host innate immunity during influenza A virus infection

C Chen, X Chi, Q Bai, J Chen - Sheng wu gong cheng xue bao …, 2015 - europepmc.org
Influenza A virus can create acute respiratory infection in humans and animals throughout
the world, and it is still one of the major causes of morbidity and mortality in humans …

Influenza a virus regulates interferon signaling and its associated genes; MxA and STAT3 by cellular miR-141 to ensure viral replication

M Alalem, E Dabous, AM Awad, N Alalem, AA Guirgis… - Virology Journal, 2023 - Springer
The antiviral response against influenza A virus (IAV) infection includes the induction of the
interferon (IFN) signaling pathway, including activation of the STATs protein family …

Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR‑146a

R Li, L Wang - Molecular Medicine Reports, 2019 - spandidos-publications.com
Influenza virus A (IVA) is one of the predominant causative agents of the seasonal flu and
has become an important cause of morbidity worldwide. Great efforts have been paid to …

MicroRNA-200c-targeted contactin 1 facilitates the replication of influenza A virus by accelerating the degradation of MAVS

S Xu, L Han, Y Wei, B Zhang, Q Wang, J Liu… - PLoS …, 2022 - journals.plos.org
Influenza A viruses (IAVs) continuously challenge the poultry industry and human health.
Elucidation of the host factors that modulate the IAV lifecycle is vital for developing antiviral …

NMI facilitates influenza A virus infection by promoting degradation of IRF7 through TRIM21

W Ouyang, M Cen, L Yang, W Zhang… - American Journal of …, 2021 - atsjournals.org
Acute respiratory infections caused by influenza A virus (IAV) spread widely and lead to
substantial morbidity and mortality. Host cell induction of type I interferon (IFN-I) plays a …

Dimethyl-Dioctadecyl-Ammonium Bromide/Poly (lactic acid) Nanoadjuvant Enhances the Immunity and Cross-Protection of an NM2e-Based Universal Influenza …

Y Gao, S Han, F Lu, Q Liu, J Yang, W Wang, Y Wang… - ACS …, 2024 - ACS Publications
For most frequent respiratory viruses, there is an urgent need for a universal influenza
vaccine to provide cross-protection against intra-and heterosubtypes. We previously …

Influenza A Infection Stimulates RIG-I and Enhances Effector Function of Primary Human NK Cells

AA Mohamed, S Soler, J Wegner, E Bartok… - International Journal of …, 2023 - mdpi.com
Immune surveillance by natural killer (NK) cells and their recruitment to sites of inflammation
renders them susceptible to viral infection, potentially modulating their effector function …

Identification of cellular microRNA-136 as a dual regulator of RIG-I-mediated innate immunity that antagonizes H5N1 IAV replication in A549 cells

L Zhao, J Zhu, H Zhou, Z Zhao, Z Zou, X Liu, X Lin… - Scientific reports, 2015 - nature.com
Abstract H5N1 influenza A virus (IAV) causes severe respiratory diseases and high mortality
rates in animals and humans. MicroRNAs are being increasingly studied to evaluate their …

Exploring the Inhibitory Effect of AgBiS2 Nanoparticles on Influenza Viruses

J Yang, L Yue, B Shen, Z Yang, J Shao, Y Miao… - International Journal of …, 2023 - mdpi.com
Influenza viruses are respiratory pathogens that are major threats to human health. Due to
the emergence of drug-resistant strains, the use of traditional anti-influenza drugs has been …

Virus-like particle–mediated delivery of the RIG-I agonist M8 induces a type I interferon response and protects cells against viral infection

E Palermo, M Alexandridi, D Di Carlo… - Frontiers in Cellular …, 2022 - frontiersin.org
Virus-Like Particles (VLPs) are nanostructures that share conformation and self-assembly
properties with viruses, but lack a viral genome and therefore the infectious capacity. In this …