The Involvement of NRF2 in Lung Cancer
AK Bauer, T Hill III, CM Alexander - Oxidative medicine and …, 2013 - Wiley Online Library
Nuclear factor, erythroid‐derived 2, like 2 (NRF2) is a key regulator of antioxidants and
cellular stress responses. The role of NRF2 in pulmonary neoplasia, a diverse disease for …
cellular stress responses. The role of NRF2 in pulmonary neoplasia, a diverse disease for …
Identification of a stable, non-canonically regulated Nrf2 form in lung cancer cells
S Mikac, M Rychłowski, A Dziadosz… - Antioxidants, 2021 - mdpi.com
Nrf2 (nuclear factor erythroid 2 (NF-E2)-related factor 2) transcription factor is recognized for
its pro-survival and cell protective role upon exposure to oxidative, chemical, or metabolic …
its pro-survival and cell protective role upon exposure to oxidative, chemical, or metabolic …
Role of NRF2 in lung cancer
M Sánchez-Ortega, AC Carrera, A Garrido - Cells, 2021 - mdpi.com
The gene expression program induced by NRF2 transcription factor plays a critical role in
cell defense responses against a broad variety of cellular stresses, most importantly …
cell defense responses against a broad variety of cellular stresses, most importantly …
Role of Nrf2 in the pathogenesis of respiratory diseases
K Mizumura, S Maruoka, T Shimizu, Y Gon - Respiratory investigation, 2020 - Elsevier
Nuclear factor erythroid 2-related factor (Nrf) 2 is a transcription factor that integrates cellular
stress signals by directing various transcriptional programs. As an evolutionarily conserved …
stress signals by directing various transcriptional programs. As an evolutionarily conserved …
“NRF2 addiction” in lung cancer cells and its impact on cancer therapy
Nuclear factor erythroid 2-like factor 2 (NRF2) is a master regulator of the antioxidant
enzymes and the detoxification proteins that play major roles in redox homeostasis …
enzymes and the detoxification proteins that play major roles in redox homeostasis …
The Nrf2-Keap1-ARE signaling pathway: the regulation and dual function of Nrf2 in cancer
DD Zhang - Antioxidants & redox signaling, 2010 - liebertpub.com
The NF-E2-related factor-2 (Nrf2) is a transcription factor that is ubiquitously expressed at
low levels in all human organs. As Nrf2 regulates a major cellular defense mechanism, tight …
low levels in all human organs. As Nrf2 regulates a major cellular defense mechanism, tight …
Identification of an unfavorable immune signature in advanced lung tumors from Nrf2-deficient mice
Aims: Activation of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway in normal
cells inhibits carcinogenesis, whereas constitutive activation of Nrf2 in cancer cells promotes …
cells inhibits carcinogenesis, whereas constitutive activation of Nrf2 in cancer cells promotes …
Prognostic and clinicopathological significance of NRF2 expression in non-small cell lung cancer: A meta-analysis
Q Wang, L Xu, G Wang, L Chen, C Li, X Jiang, H Gao… - Plos one, 2020 - journals.plos.org
Nuclear factor erythroid 2-related factor 2 (NRF2) functions as a transcription factor and
regulates a wide array of antioxidant and stress-responsive genes. NRF2 has been widely …
regulates a wide array of antioxidant and stress-responsive genes. NRF2 has been widely …
An update on the role of Nrf2 in respiratory disease: molecular mechanisms and therapeutic approaches
J Lee, J Jang, SM Park, SR Yang - International Journal of Molecular …, 2021 - mdpi.com
Nuclear factor erythroid 2-related factor (Nrf2) is a transcriptional activator of the cell
protection gene that binds to the antioxidant response element (ARE). Therefore, Nrf2 …
protection gene that binds to the antioxidant response element (ARE). Therefore, Nrf2 …
The KEAP1–NRF2 system as a molecular target of cancer treatment
K Taguchi, M Yamamoto - Cancers, 2020 - mdpi.com
Simple Summary Nuclear factor erythroid-derived 2-like 2 (encoded by the Nfe2l2 gene;
NRF2) is a transcription factor that regulates a variety of cytoprotective genes, including …
NRF2) is a transcription factor that regulates a variety of cytoprotective genes, including …